2-(isoxazol-4-yl)ethyl methanesulfonate | 1280210-94-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-(isoxazol-4-yl)ethyl methanesulfonate
• 英文别名: 2-(1,2-Oxazol-4-yl)ethyl methanesulfonate
• CAS: 1280210-94-7
• 化学式: C₆H₉NO₄S
• 分子量: 191.208
• InChiKey: NUMKFSCKZSUXGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(isoxazol-4-yl)ethyl methanesulfonate 在 potassium carbonate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 13.0h， 生成 tert-butyl (S)-((3'-chloro-2'-(2-chloro-3-(5-(2-(isoxazol-4-yl)ethyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-2-carboxamido)phenyl)-6-methoxy-[2,4'-bipyridin]-5-yl)methyl)((5-oxopyrrolidin-2-yl)methyl)carbamate
  参考文献：
  名称：

  [EN] SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME
  [FR] COMPOSÉS D'IMIDAZOAMIDE SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  The present disclosure includes substituted imidazoamide compounds of Formula (I), analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent cancer in a patient.

  公开号：

  WO2024018403A1
• 作为产物：
  描述：

  2-异噁唑-4-乙醇 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以94 %的产率得到2-(isoxazol-4-yl)ethyl methanesulfonate
  参考文献：
  名称：

  [EN] SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME
  [FR] COMPOSÉS D'IMIDAZOAMIDE SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  The present disclosure includes substituted imidazoamide compounds of Formula (I), analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent cancer in a patient.

  公开号：

  WO2024018403A1

文献信息

• SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES
  申请人：Cox Jason M.

  公开号：US20120149683A1

  公开（公告）日：2012-06-14

  The present invention is directed to novel substituted aminopiperidines of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-ÏV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及结构式I的新型取代氨基哌啶化合物，它们是二肽基肽酶-IV酶的抑制剂，并且在治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病和特别是2型糖尿病方面具有用途。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的这些疾病方面使用这些化合物和组合物。
• US8716482B2
  申请人：——

  公开号：US8716482B2

  公开（公告）日：2014-05-06