1-cyclopropylidene[3.3]heptane | 675877-44-8

• 分子结构分类: 有机化合物 - 碳氢化合物 - 多环烃
• 英文名称: 1-cyclopropylidene[3.3]heptane
• 英文别名: 3-Cyclopropylidenespiro[3.3]heptane
• CAS: 675877-44-8
• 化学式: C₁₀H₁₄
• 分子量: 134.221
• InChiKey: XMFBIBJBFJIXOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-cyclopropylidene[3.3]heptane 在 碳酸氢钠 、 间氯过氧苯甲酸 、 三氟化硼乙醚 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 Dispiro<2.0.3.3>decan-5-on 、 dispiro[3.0.3.2]decan-1-one
  参考文献：
  名称：

  A new approach to helical primary structures of four-membered rings: (P)- and (M)-tetraspiro[3.0.0.0.3.2.2.2]hexadecane

  摘要：

  A new approach to helical primary structures of four-membered rings uses a cycloaddition of a trimethylenketeniminium salt to suitable tailored methylenecyclobutanes to assemble the desired carbon framework. The results are short and effective syntheses of (M)-trispiro[3.0.0.3.2.2]tridecane [(M-5], and (P)- and (M)-tetraspiro[3.0.0.0.3.2.2.2]hexadecane [(P)- and (M)-24]. Unlike helices of three-membered rings, the specific rotation decreases, as the length of the helix increases. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.11.081
• 作为产物：
  描述：

  螺[3.3]庚烷-1-酮 、 溴化环丙基三苯鏻 在 potassium tert-butylate 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 1-cyclopropylidene[3.3]heptane
  参考文献：
  名称：

  A new approach to helical primary structures of four-membered rings: (P)- and (M)-tetraspiro[3.0.0.0.3.2.2.2]hexadecane

  摘要：

  A new approach to helical primary structures of four-membered rings uses a cycloaddition of a trimethylenketeniminium salt to suitable tailored methylenecyclobutanes to assemble the desired carbon framework. The results are short and effective syntheses of (M)-trispiro[3.0.0.3.2.2]tridecane [(M-5], and (P)- and (M)-tetraspiro[3.0.0.0.3.2.2.2]hexadecane [(P)- and (M)-24]. Unlike helices of three-membered rings, the specific rotation decreases, as the length of the helix increases. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.11.081

文献信息

• A new approach to helical primary structures of four-membered rings: (P)- and (M)-tetraspiro[3.0.0.0.3.2.2.2]hexadecane
  作者：Lutz Fitjer、Andreas Kanschik、Ralf Gerke

  DOI：10.1016/j.tet.2003.11.081

  日期：2004.1

  A new approach to helical primary structures of four-membered rings uses a cycloaddition of a trimethylenketeniminium salt to suitable tailored methylenecyclobutanes to assemble the desired carbon framework. The results are short and effective syntheses of (M)-trispiro[3.0.0.3.2.2]tridecane [(M-5], and (P)- and (M)-tetraspiro[3.0.0.0.3.2.2.2]hexadecane [(P)- and (M)-24]. Unlike helices of three-membered rings, the specific rotation decreases, as the length of the helix increases. (C) 2003 Elsevier Ltd. All rights reserved.