| 1009087-13-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1009087-13-1
• 化学式: C₂₇H₂₃F₃N₄O₅S₂
• 分子量: 604.631
• InChiKey: WAMRMRXFJBBXMX-OWJIYDKWSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 反应 0.02h， 生成
  参考文献：
  名称：

  Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

  摘要：

  The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme.

  DOI：

  10.1016/j.bmcl.2007.11.012