2-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-indole | 26882-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-indole
• 英文别名: 2-<1-Methyl-1,2,3,6-tetrahydro-pyridyl-(4)>-indol；2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indole
• CAS: 26882-92-8
• 化学式: C₁₄H₁₆N₂
• 分子量: 212.294
• InChiKey: DLSCAGIOJJOTQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-indole 反应 1.0h， 以34%的产率得到2-(4-methoxy-1-methyl-4-piperidyl)indole
  参考文献：
  名称：

  Silhankova, Alexandra; Davidova, Dagmar; Sputova, Michaela, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 5, p. 1298 - 1304

  摘要：

  DOI：

文献信息

• SILHANKOVA A.; DAVIDOVA D.; SPUTOVA M.; TRSKA P.; VACULIKOVA D.; VLKOVA D+, COLLECT. CZECHOSL. CHEM. COMMUN., 52,(1987) N 5, 1298-1304
  作者：SILHANKOVA A.、 DAVIDOVA D.、 SPUTOVA M.、 TRSKA P.、 VACULIKOVA D.、 VLKOVA D+

  DOI：——

  日期：——
• INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE
  申请人：NPS Allelix Corp.

  公开号：EP1196380A2

  公开（公告）日：2002-04-17
• US6608079B1
  申请人：——

  公开号：US6608079B1

  公开（公告）日：2003-08-19
• [EN] HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MIGRAINE<br/>[FR] COMPOSES HETEROCYCLIQUES DESTINES AU TRAITEMENT DE LA MIGRAINE
  申请人：NPS ALLELIX CORP

  公开号：WO2001005758A2

  公开（公告）日：2001-01-25

  Described herein are compounds useful in the treatment of migraine, which have general formulae (I), (II), (III) and (IV), wherein : W is a CH group or an N atom ;Z is N or C-R4; B and D are selected independently from CH and N, with the proviso that at least one of B and D is CH and with the further proviso that one of B and D can represent N only when W and Z are both other than N; A is a group of Formula (II), (III) or (IV), such that group A contains at least 1 N atom ; NR7 is either -NH- or -N=--- is a single or double bond ; X is an N atom, a CH group or a C(OH) group when --- is a single bond; or, when --- is a double bond, a C atom; Y is an NH, N-alkyl, N-benzyl or CH2 group; U and V each represent an N atom or a CH group, with the proviso that both cannot be N; a and b are, independently, 0 or 1; c is an integer from 0 to 3; d is an integer from 1 to 3; e is an integer from 1 to 2; f is an integer from 0 to 3; g is an integer from 3 to 6 and h is an integer from 2 to 3; such that the sum of c and d is at least 2 and the sum of e and f is at least 2; R1 is selected from the group consisting of H, alkyl, alkyloxy, alkanoyl, aminoalkylenyl, alkylaminoalkylenyl, a hydroxyalkylenyl group, an alkyloxyalkylenyl group, a cycloalkyl group, a cycloalkylalkylenyl group, a heterocycloalkyl group, a heterocycloalkylalkylenyl group, an aryl group, a heterocycloaryl group, an amido group, a thioamido group, an arylcarbonyl group and an arylsulfonyl group; R2 and R3 are independently selected from the group consisting of H, alkyl, cycloalkyl, alkenyl and optionally-substituted benzyl; or R2 and R3, together with the nitrogen atom to which they are attached, may form a mono- or bi-cyclic group containing up to 10 carbon atoms and which, in addition, may contain a second heteroatom selected from the group consisting of N, S and O, and which may contain one or more substituents selected from the group consisting of alkyl, hydroxy, hydroxymethyl, alkyloxymethyl, amino and substituted amino; R4 is selected from the group consisting of H, alkyl and cycloalkyl; CR5 represents a group selected from -CH2-, CH(OH)-, -C(O)-, -CH(alkyl)- and -CH(alkyloxy)-; R6 is selected from the group consisting of H, alkyl, aryl, halogen, hydroxy, alkyloxy, amino, monoalkylamino and di-substituted alkylamino; and salts and solvates thereof.
• Silhankova, Alexandra; Davidova, Dagmar; Sputova, Michaela, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 5, p. 1298 - 1304
  作者：Silhankova, Alexandra、Davidova, Dagmar、Sputova, Michaela、Trska, Petr、Vaculikova, Dana、et al.

  DOI：——

  日期：——