2-{[(3-nitrophenyl)-5-phenyl-1H-pyrazol-4-yl]methyl}-1H-benzimidazole | 1159612-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-{[(3-nitrophenyl)-5-phenyl-1H-pyrazol-4-yl]methyl}-1H-benzimidazole
• CAS: 1159612-93-7
• 化学式: C₂₃H₁₇N₅O₂
• 分子量: 395.42
• InChiKey: JXIIRHLJLWOELU-UHFFFAOYSA-N

物化性质

• 熔点：
  240-241.5 °C(Solvent: Ethanol; Water)
• 沸点：
  772.4±60.0 °C(predicted)
• 密度：
  1.370±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  2-[6-(3-nitrophenyl)-3-phenylpyridazin-4-yl]-1H-benzimidazole 在 氨 作用下， 以 水 为溶剂， 以24%的产率得到2-{[(3-nitrophenyl)-5-phenyl-1H-pyrazol-4-yl]methyl}-1H-benzimidazole
  参考文献：
  名称：

  Recyclization of 2-(3,6-diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles to 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles

  摘要：

  2-(3,6-Diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles undergo a previously unknown type of recyclization of the pyridazine ring to a pyrazole to give 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles. It is suggested that the mechanism of this conversion, which includes formation of a secondary enhydrazine group in the diazine ring and its subsequent contraction, occurs after the intramolecular formation and opening of a cyclopropane ring.

  DOI：

  10.1007/s10593-008-0108-3