4-羟基-3-(羟甲基)-3-甲基丁酸 | 191859-22-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 4-羟基-3-(羟甲基)-3-甲基丁酸
• 英文名称: bis(hydroxymethyl)propionic acid
• 英文别名: 4-Hydroxy-3-(hydroxymethyl)-3-methylbutanoic acid
• CAS: 191859-22-0
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: BFWKQDMSPGJDGS-UHFFFAOYSA-N

物化性质

• 沸点：
  379.8±32.0 °C(Predicted)
• 密度：
  1.263±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-羟基-3-(羟甲基)-3-甲基丁酸 、 溴甲苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 苄基3-羟基-2-(羟基甲基)-2-甲基丙酸酯
  参考文献：
  名称：

  ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice

  摘要：

  Treatment of medulloblastoma (MB) is challenging due to diverse genetic make-up, chemoresistance and inefficient drug transport across the blood brain barrier (BBB). Since hedgehog (Hh) signaling regulates cancer cell proliferation and tumorigenicity, Hh inhibitors have the potential to treat sonic Hh driven MB (SHH-MB), but their repeated use develops chemoresistance due to mutations in smoothened (SMO). Herein, we aimed to overcome these problems by modulating GLI transcription using JQ1, which is a small molecule BRD4 inhibitor. JQ1 inhibited HD-MB03 and DAOY cell proliferation, with the IC50 of 402 and 4220 nM, respectively. JQ1 inhibited colony formation, but increased apoptosis in HD-MB03 and DAOY cells. Western blot analysis confirmed significant inhibition of GLI1 and c-MYC protein expression in DAOY and HD-MB03 cells, respectively. JQ1 was encapsulated into apolipoprotein (ApoE) mimetic peptide decorated nanoparticles (ApoE-NPs), with the mean particle size of 64 nm and drug loading of 10% (w/w). ApoE-NPs increased JQ1 concentration in the tumor by 5 and 8 folds at 6 and 24 h after systemic administration into orthotopic MB tumor bearing NSG mice compared to non-targeted JQ1 loaded NPs. Although there was also modest increase in JQ1 delivery to the liver, there was no hepatotoxicity as evidenced by H&E staining and little increase in serum ALT and AST after treatment with JQ1 loaded ApoE-NPs. There was also significant decrease in the orthotopic MB tumor burden after systemic administration of JQ1 loaded ApoE- NPs at the dose of 10 mg/kg every 3rd day for a total of 8 injections. In conclusion, JQ1 loaded NPs have the potential to treat Group 3 and SHH driven MB in mice.

  DOI：

  10.1016/j.jconrel.2020.04.053

文献信息

• Fluorinated crosslinker and composition
  申请人：——

  公开号：US20020111518A1

  公开（公告）日：2002-08-15

  Fluorinated multifunctional alcohols containing at least 3 primary hydroxyl groups are disclosed. Such alcohols allow for easy synthesis of multifunctional crosslinkers such as acrylates, epoxies and vinyl ethers. The multifunctional crosslinkers are used in fluorinated optical coating and waveguide compositions to increase curing speed and crosslinking density.

  揭示了含有至少3个主要羟基的氟化多功能醇。这些醇可用于易于合成多功能交联剂，如丙烯酸酯、环氧树脂和乙烯醚。多功能交联剂用于氟化光学涂层和波导组合物中，以增加固化速度和交联密度。
• Polycarboxylic acid compounds for the treatment of fibrious amino acid based substrates, especially hair
  申请人：Momentive Performance Materials, Inc.

  公开号：US10617617B1

  公开（公告）日：2020-04-14

  This invention relates to the use of polycarboxylic acid compounds, aqueous compositions comprising the same, cosmetic compositions comprising the same, in particular, hair care compositions, and their use for the treatment of hair, and a process for the treatment of hair comprising the use of said cosmetic compositions.

  本发明涉及使用多羧酸化合物，包含它们的水性组合物，包含它们的化妆品组合物，特别是头发护理组合物，以及它们用于头发治疗的用途，以及包含使用该化妆品组合物的头发处理过程。
• AQUEOUS COMPOSITIONS FOR HAIR TREATMENT COMPRISING POLYORGANOSILOXANES WITH POLYHYDROXYAROMATIC MOIETIES
  申请人：Momentive Performance Materials Inc.

  公开号：US20180346653A1

  公开（公告）日：2018-12-06

  This invention relates to aqueous compositions for hair treatment, comprising polyorganosiloxanes A) having di- and trihydroxy-substituted aromatic groups and at least one surfactant B) selected from cationic surfactants B1) and anionic surfactants B2) in a certain weight ratio of the surfactant B) to the polyorganosiloxane A), and said aqueous compositions having a certain pH. The invention further relates to hair treatment compositions, comprising said aqueous compositions and to hair treatment processes using said aqueous compositions or hair treatment compositions.

  本发明涉及用于头发处理的水基组合物，包括具有二羟基和三羟基取代芳基的聚有机硅氧烷A）和至少一种阳离子表面活性剂B1）和阴离子表面活性剂B2）中选择的表面活性剂B）在一定的重量比下与聚有机硅氧烷A）混合，并且所述水基组合物具有一定的pH值。本发明还涉及头发处理组合物，包括所述的水基组合物，以及使用所述的水基组合物或头发处理组合物进行头发处理的处理过程。
• Adhesive resin composition and adhesive film
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0911353A1

  公开（公告）日：1999-04-28

  An adhesive resin composition comprising polyester polyurethane having a number average molecular weight of 8,000 - 100,000 and an epoxy resin having two or more epoxy groups per molecule, said polyester polyurethane having an acid value of 100 - 1,000 equivalent/ 106 g and the proportion of polyester polyurethane having a molecular weight of not more than 5,000 is not more than 20 wt% and an adhesive film obtained from the adhesive resin composition. The adhesive resin composition and the adhesive film of the present invention have a longer working life and are superior in adhesive property, heat resistance and water resistance.

  一种粘合剂树脂组合物，由平均分子量为 8,000 - 100,000 的聚酯聚氨酯和每个分子具有两个或两个以上环氧基团的环氧树脂组成，所述聚酯聚氨酯的酸值为 100 - 1,000 当量/106克，分子量不超过 5,000 的聚酯聚氨酯的比例不超过 20 wt%，以及由该粘合剂树脂组合物制成的粘合膜。本发明的粘合剂树脂组合物和粘合剂薄膜的工作寿命更长，粘合性能、耐热性和耐水性更优越。
• Polymerizable composition and image recording material containing the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1522557A1

  公开（公告）日：2005-04-13

  A polymerizable composition comprising: a dendrimer having at least two polymerizable groups within a molecule; a radical initiator; and an alkali-soluble polymer, and an image recording material comprising a support and a recording layer comprising a polymerizable composition containing a dendrimer having at least two polymerizable groups within a molecule, a radical initiator and an alkali-soluble polymer.

  一种可聚合组合物，包含：分子内至少有两个可聚合基团的树枝状聚合物；一种自由基引发剂；和一种碱溶性聚合物；以及一种图像记录材料，包含一个支撑体和一个记录层，记录层包含一种可聚合组合物，该组合物包含分子内至少有两个可聚合基团的树枝状聚合物、一种自由基引发剂和一种碱溶性聚合物。