(3aR,5R,6R,6aR)-5-[2-[[(3aR,5R,6R,6aR)-5-(2-methoxyethyl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl]methoxy]ethyl]-2,2-dimethyl-6-(phenylmethoxymethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole | 1350963-48-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3aR,5R,6R,6aR)-5-[2-[[(3aR,5R,6R,6aR)-5-(2-methoxyethyl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl]methoxy]ethyl]-2,2-dimethyl-6-(phenylmethoxymethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole
• CAS: 1350963-48-2
• 化学式: C₂₈H₄₂O₉
• 分子量: 522.636
• InChiKey: UHNUEYPXMBQDJV-DSUYJHQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (3aR,5R,6R,6aR)-5-[2-[[(3aR,5R,6R,6aR)-5-(2-methoxyethyl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl]methoxy]ethyl]-2,2-dimethyl-6-(phenylmethoxymethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole 在 吡啶 、 4-二甲氨基吡啶 、 N,O-双三甲硅基乙酰胺 、 三氟甲磺酸三甲基硅酯 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 36.0h， 生成 [(2R,3R,4R,5R)-4-[2-[(2R,3R,4R,5R)-4-acetyloxy-5-(2,4-dioxopyrimidin-1-yl)-3-(phenylmethoxymethyl)oxolan-2-yl]ethoxymethyl]-2-(2,4-dioxopyrimidin-1-yl)-5-(2-methoxyethyl)oxolan-3-yl] acetate
  参考文献：
  名称：

  Synthesis of nonionic ether-backbone analogues of RNA from pseudooligosaccharides

  摘要：

  Uracil nucleosides with internucleosidic ether linkage as nonionic analogues of RNA were synthesized by glycosylation of ether-backbone pseudooligosaccharides. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.139
• 作为产物：
  描述：

  (3aR,5R,6R,6aR)-6-((benzyloxy)methyl)-5-(2-(((3aR,5S,6R,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-yl)methoxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole 在 dimethyl sulfide borane 、 水 、 sodium hydride 、 溶剂黄146 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 二氯甲烷 为溶剂， 反应 47.0h， 生成 (3aR,5R,6R,6aR)-5-[2-[[(3aR,5R,6R,6aR)-5-(2-methoxyethyl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl]methoxy]ethyl]-2,2-dimethyl-6-(phenylmethoxymethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole
  参考文献：
  名称：

  Synthesis of nonionic ether-backbone analogues of RNA from pseudooligosaccharides

  摘要：

  Uracil nucleosides with internucleosidic ether linkage as nonionic analogues of RNA were synthesized by glycosylation of ether-backbone pseudooligosaccharides. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.139

文献信息

• Synthesis of nonionic ether-backbone analogues of RNA from pseudooligosaccharides
  作者：Prithwish Kumar Jana、Soumendra Nath Das、Sukhendu B. Mandal、Anup Bhattacharjya

  DOI：10.1016/j.tetlet.2011.09.139

  日期：2011.12

  Uracil nucleosides with internucleosidic ether linkage as nonionic analogues of RNA were synthesized by glycosylation of ether-backbone pseudooligosaccharides. (C) 2011 Elsevier Ltd. All rights reserved.