α,β-diacetoxy-N-hydroxysuccinimide | 78814-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: α,β-diacetoxy-N-hydroxysuccinimide
• 英文别名: (4-Acetyloxy-1-hydroxy-2,5-dioxopyrrolidin-3-yl) acetate
• CAS: 78814-84-3
• 化学式: C₈H₉NO₇
• 分子量: 231.162
• InChiKey: IHHHKBZUKKZSJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  α,β-diacetoxy-N-hydroxysuccinimide 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 48.0h， 生成 Z-D-Ala-D-Ala-OEt
  参考文献：
  名称：

  用于对映选择性肽合成的旋光N-羟基酒石酰胺

  摘要：

  制备了光学活性的N-羟基酒石酰亚胺。使ZL-丙氨酸的1,3,4-三羟基琥珀酰亚胺酯和ZD-丙氨酸的1-羟基-3,4-二乙酰氧基琥珀酰亚胺酯与D，L-丙氨酸酯反应以生成LL-形式和DD-形式的Z-Ala-Ala -OEt分别（光学收率100％）。

  DOI：

  10.1016/s0040-4039(01)90249-7
• 作为产物：
  描述：

  2,3-diacetyloxy-4-oxo-4-(phenylmethoxyamino)butanoic acid 在 palladium on activated charcoal 氢气 、 乙酸酐 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 α,β-diacetoxy-N-hydroxysuccinimide
  参考文献：
  名称：

  用于对映选择性肽合成的旋光N-羟基酒石酰胺

  摘要：

  制备了光学活性的N-羟基酒石酰亚胺。使ZL-丙氨酸的1,3,4-三羟基琥珀酰亚胺酯和ZD-丙氨酸的1-羟基-3,4-二乙酰氧基琥珀酰亚胺酯与D，L-丙氨酸酯反应以生成LL-形式和DD-形式的Z-Ala-Ala -OEt分别（光学收率100％）。

  DOI：

  10.1016/s0040-4039(01)90249-7

文献信息

• Process for the preparation of substituted phenols
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1967505A1

  公开（公告）日：2008-09-10

  A substituted phenolic compound is prepared by oxidizing a substituted diarylethane compound with oxygen in the presence of a nitrogen-containing cyclic compound, and treating the oxidized product with an acid. The nitrogen-containing cyclic compound includes, as a constituent of its ring, a skeleton represented by following Formula (I): wherein X is oxygen atom or an -OR group, where R is hydrogen atom or a hydroxyl-protecting group. The substituted diarylethane compound is represented by following Formula (1): wherein each of Ring Ar1 and Ring Ar2 is independently a monocyclic or polycyclic aromatic carbocyclic ring; Y1 is an electron-donating group; Y2 is an electron-withdrawing group; "p" is an integer of 1 or more; and "q" is an integer of 0 or more. The substituted phenolic compound is represented by following Formula (2): wherein Ring Ar1, Y1, and "p" are as defined above.

  一种取代酚化合物是通过在含氮环化合物存在下氧化取代二芳乙烷化合物制备的，并且用酸处理氧化产物。含氮环化合物包括其环中的一个组分是由以下式（I）表示的骨架：其中X是氧原子或-OR基团，其中R是氢原子或羟基保护基团。取代二芳乙烷化合物由以下式（1）表示：其中Ar1环和Ar2环中的每一个独立地是单环或多环芳香碳环；Y1是电子给予基团；Y2是电子吸引基团；“p”是1或更多的整数；“q”是0或更多的整数。取代酚化合物由以下式（2）表示：其中Ar1环，Y1和“p”如上定义。
• METHOD FOR PRODUCING OXIDE
  申请人：DAICEL CORPORATION

  公开号：US20160159722A1

  公开（公告）日：2016-06-09

  Provided is a method of oxidizing a substrate with excellent oxidizing power to yield a corresponding oxide. The method can employ a commercially available imide compound as intact as a catalyst and can produce the oxide in a high yield under mild conditions. A method for producing an oxide according to the present invention includes performing oxidation of a substrate in the presence of oxygen and ozone under catalysis of an imide compound to yield a corresponding oxide. The imide compound has a cyclic imide skeleton represented by Formula (I). In the formula, n is selected from 0 and 1; and X is selected from an oxygen atom and an —OR group, where R is selected from hydrogen and a hydroxy-protecting group.

  提供了一种氧化底物以产生相应氧化物的方法，该方法可以利用商业可获得的亚酰胺化合物作为催化剂，并在温和条件下高产率地产生氧化物。根据本发明的一种制备氧化物的方法包括在氧气和臭氧的存在下，在亚酰胺化合物的催化下对底物进行氧化，以产生相应的氧化物。该亚酰胺化合物具有由式（I）表示的环状亚酰胺骨架。在该式中，n选择自0和1；X选择自氧原子和—OR基团，其中R选择自氢和羟基保护基团。
• Process for producing azine compounds and oxime compounds
  申请人：——

  公开号：US20030204084A1

  公开（公告）日：2003-10-30

  A process comprising allowing a peroxide compound represented by following Formula (2): 1 wherein R a , R b , R c and R d are the same or different and are each a hydrogen atom or a hydrocarbon group, and wherein R a and R b , R c and R d may be combined to form a ring together with the adjacent carbon atom, respectively, to react with ammonia and water to yield an azine compound represented by following Formula (3): 2 wherein R a , R b , R c and R d have the same meanings as defined above, or oxime compounds represented by following Formulae (4 a ) and/or (4 b ): 3 wherein R a , R b , R c and R d have the same meanings as defined above, in the presence of a nitrogen-containing cyclic compound constitutively having a skeleton represented by following Formula (A) in its ring: 4 wherein X is one of an oxygen atom and an —OR group, and wherein R is one of a hydrogen atom and a hydroxyl-protecting group. This process can produce an oxime compound or an azine compound useful as a material for oxime compounds from low-cost materials by easy and simple procedures.

  一种过程包括允许由以下式（2）表示的过氧化物化合物：其中Ra、Rb、Rc和Rd相同或不同，每个都是氢原子或烃基，且Ra和Rb、Rc和Rd可以分别与相邻的碳原子结合形成环，以与氨和水反应生成由以下式（3）表示的偶氮化合物：其中Ra、Rb、Rc和Rd的含义与上述定义相同，或者在具有以下式（A）中的环中具有骨架的含氮环化合物的存在下生成由以下式（4a）和/或（4b）表示的肟化合物：其中Ra、Rb、Rc和Rd的含义与上述定义相同，在X为氧原子和-OR基团之一，R为氢原子和羟基保护基团之一的情况下。该过程可以通过简单易行的步骤从低成本材料中产生用作肟化合物材料的肟化合物或偶氮化合物。
• Process for producing organic compounds using nitrites
  申请人：——

  公开号：US20030171618A1

  公开（公告）日：2003-09-11

  A process produces an organic compound by allowing (A) a compound capable of generating a free radical to react with (B) at least one of esters and salts of nitrous acid in the presence of a nitrogen-containing cyclic compound constitutively having a skeleton represented by following Formula (i) in its ring: 1 wherein X is an oxygen atom or an —OR group, and wherein R is a hydrogen atom or a hydroxyl-protecting group. Examples of the nitrogen-containing cyclic compound are cyclic imide compounds having a cyclic imide skeleton represented by following Formula (I): 2 wherein n is 0 or 1; X is an oxygen atom or an —OR group, and wherein R is a hydrogen atom or a hydroxyl-protecting group.

  该过程通过允许（A）具有产生自由基的化合物与（B）硝酸酯和盐中至少一种在氮含环腺嘌呤化合物的存在下反应来产生有机化合物，该氮含环腺嘌呤化合物在其环中具有以下式（i）所表示的骨架：1其中X为氧原子或-OR基团，R为氢原子或羟基保护基团。氮含环腺嘌呤化合物的示例是具有以下式（I）所表示的环状咪唑酰衍生物骨架的环状咪唑化合物：2其中n为0或1；X为氧原子或-OR基团，R为氢原子或羟基保护基团。
• METHOD FOR PRODUCING ESTER OR LACTONE
  申请人：Ishii Yasutaka

  公开号：US20100029956A1

  公开（公告）日：2010-02-04

  Disclosed is a method for producing an ester or lactone in which a secondary alcohol represented by following Formula (1) (wherein R a and R b each represent an organic group, or R a and R b may be combined to form a ring together with the adjacent carbon atom) is oxidized by molecular oxygen in the presence of a nitrogen-containing cyclic compound containing a structure represented by following Formula (I) [wherein X represents an oxygen atom or an —OR group (wherein R represents a hydrogen atom or hydroxyl-protecting group)] as a constituent of its ring, and at least one of a fluorine-containing alcohol and a fluorinated sulfonic acid, and thereby yields a compound represented by following Formula (2):

  本发明公开了一种制备酯或内酯的方法，其中在含有下式（1）所表示的二级醇（其中Ra和Rb各自表示一个有机基团，或者Ra和Rb可以与相邻的碳原子一起形成环）的分子氧存在下，通过含有下式（I）所表示的结构的含氮环状化合物作为其环中成分，其中X表示氧原子或—OR基团（其中R表示氢原子或羟基保护基团），以及至少一种含氟醇和含氟磺酸之一，从而得到下式（2）所表示的化合物的氧化反应方法。