1-Phenyl-4-chloro-pyrazolo<4,3-c>pyridin | 41372-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Phenyl-4-chloro-pyrazolo<4,3-c>pyridin
• 英文别名: 4-Chlor-1-phenyl-1H-pyrazolo<4,3-c>pyridin；4-chloro-1-phenyl-1H-pyrazolo[4,3-c]pyridine；1h-Pyrazolo[4,3-c]pyridine,4-chloro-1-phenyl-；4-chloro-1-phenylpyrazolo[4,3-c]pyridine
• CAS: 41372-96-7
• 化学式: C₁₂H₈ClN₃
• 分子量: 229.669
• InChiKey: QDGBEFRAQOTODH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS
  申请人：BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

  公开号：US20170355700A1

  公开（公告）日：2017-12-14

  Pyrazolopyrimidine compounds for inhibition of isoprenoid biosynthesis have a formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), R 1 includes an alkyl group and R 2 includes an optionally substituted moiety selected from the group consisting of an optionally substituted benzyl group, an optionally substituted phenethyl group, an optionally substituted ethanol group, an optionally substituted ethyl acetate group, an optionally substituted methyl furan group, an optionally substituted 3-ethyl indole group, and a lower alkyl group. Compositions containing pyrazolopyrimidine compounds and methods for using pyrazolopyrimidine compounds are described.

  吡唑吡咯嘧啶类化合物用于抑制异戊二烯生物合成，其化学式（I）或其药学上可接受的盐。在式（I）中，R1包括一个烷基基团，R2包括一个从可选取的苯甲基基团、可选取的苯乙基基团、可选取的乙醇基团、可选取的乙酸乙酯基团、可选取的甲基呋喃基团、可选取的3-乙基吲哚基团和较低烷基基团中选择的可选取的取代基团。描述了含有吡唑吡咯嘧啶类化合物的组合物和使用吡唑吡咯嘧啶类化合物的方法。
• Pyrazolopyrimidine antibacterial agents
  申请人：BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

  公开号：US10155766B2

  公开（公告）日：2018-12-18

  Pyrazolopyrimidine compounds for inhibition of isoprenoid biosynthesis have a formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), R1 includes an alkyl group and R2 includes an optionally substituted moiety selected from the group consisting of an optionally substituted benzyl group, an optionally substituted phenethyl group, an optionally substituted ethanol group, an optionally substituted ethyl acetate group, an optionally substituted methyl furan group, an optionally substituted 3-ethyl indole group, and a lower alkyl group. Compositions containing pyrazolopyrimidine compounds and methods for using pyrazolopyrimidine compounds are described.

  用于抑制异戊二烯生物合成的吡唑嘧啶化合物具有式(I) 或其药学上可接受的盐。在式 (I) 中，R1 包括一个烷基，R2 包括一个任选取代的分子，该分子选自任选取代的苄基、任选取代的苯乙基、任选取代的乙醇基、任选取代的乙酸乙酯基、任选取代的甲基呋喃基、任选取代的 3-乙基吲哚基和低级烷基组成的组。描述了含有吡唑嘧啶化合物的组合物和使用吡唑嘧啶化合物的方法。