8-(2-Methoxyphenyl)-2-methyloctan-3-one | 1103190-77-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 8-(2-Methoxyphenyl)-2-methyloctan-3-one
• 英文别名: 8-(2-methoxyphenyl)-2-methyloctan-3-one
• CAS: 1103190-77-7
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: SSLOXYXWMWDDTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-Methoxyphenylmagnesium bromide 、 8-bromo-2-methyloctan-3-one 在 四甲基乙二胺 、 cobalt(III) acetylacetonate 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 以88%的产率得到8-(2-Methoxyphenyl)-2-methyloctan-3-one
  参考文献：
  名称：

  A New Efficient Catalytic System for the Chemoselective Cobalt-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Primary and Secondary Alkyl Bromides

  摘要：

  The cobalt-catalyzed alkylation of aromatic Grignard reagents is performed in good yields by using a new simple and efficient catalytic system: CoCl(2)/TMEDA (1:1). Primary and secondary cyclic or acyclic alkyl bromides were used successfully. The reaction is highly chemoselective since ester, amide, and keto groups are tolerated. The procedure is inexpensive and very easy to carry out on a larger scale.

  DOI：

  10.1021/ol802362e

文献信息

• A New Efficient Catalytic System for the Chemoselective Cobalt-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Primary and Secondary Alkyl Bromides
  作者：Gérard Cahiez、Christophe Chaboche、Christophe Duplais、Alban Moyeux

  DOI：10.1021/ol802362e

  日期：2009.1.15

  The cobalt-catalyzed alkylation of aromatic Grignard reagents is performed in good yields by using a new simple and efficient catalytic system: CoCl(2)/TMEDA (1:1). Primary and secondary cyclic or acyclic alkyl bromides were used successfully. The reaction is highly chemoselective since ester, amide, and keto groups are tolerated. The procedure is inexpensive and very easy to carry out on a larger scale.