1-Phenyl-3-amino-5-hydroxypyrazole | 90564-80-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Phenyl-3-amino-5-hydroxypyrazole
• 英文别名: 3-amino-5–hydroxy-1-phenylpyrazole；3-amino-5-hydroxy-1-phenylpyrazole；3-amino-1-phenylpyrazol-5-one；5-amino-2-phenyl-2,4-dihydro-pyrazol-3-one；3-amino-1-phenyl-2-pyrazolin-5-one；3-Amino-5-hydroxy-1-phenyl-pyrazol
• CAS: 90564-80-0
• 化学式: C₉H₉N₃O
• 分子量: 175.19
• InChiKey: NJOPPPORAZRGOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  13.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.07
• 氢给体数：
  2.0
• 氢受体数：
  4.0

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

反应信息

• 作为反应物：
  描述：

  1-Phenyl-3-amino-5-hydroxypyrazole 在 吡啶 、 phthalimidesulfenyl chloride 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 spiro[(3-amino-1-phenylpyrazol-5-one)-4,6'-(3',4'-dimethyl-6'H-2',5'-dihydrothiane)]
  参考文献：
  名称：

  基于3-甲基-（氨基）-1-苯基吡唑-5-酮的含硫螺环化合物

  摘要：

  DOI：

  10.1007/bf02283543

文献信息

• Novel heterocyclic disazo dyes containing pyrazole and phenylpyrazole. part 1: Synthesis, characterization, solvent polarity and acid-base sensitive characteristics
  作者：Aykut Demirçalı

  DOI：10.1016/j.molstruc.2021.129960

  日期：2021.5

  A series of diazotised aniline and aniline derivative compounds were reacted with solution of malononitrile in pyridine at 0–5 °C were obtained 1a-1m compounds. Then 4-arylazo-3,5-diamino-1H-pyrazole (2a-2m) derivatives were synthesized by coupling arylazo malononitrile compounds with hydrazine. Finally, the synthesized pyrazole derivative 2a-2m compounds were again diazotised. By reacting these diazotised

  在0〜5℃下，将一系列重氮化的苯胺和苯胺衍生物与丙二腈在吡啶中的溶液反应，得到1a-1m的化合物。然后通过将芳基偶氮丙二腈化合物与肼偶合来合成4-芳基偶氮-3，5-二氨基-1H-吡唑（2a-2m）衍生物。最后，将合成的吡唑衍生物2a-2m化合物再次重氮化。通过使这些重氮化的化合物与3-氨基-5-羟基-1-苯基吡唑反应，得到了新的13种杂环二偶氮染料（3a-3m）加入了染料文献和染料行业。这些新合成的化合物的结构通过元素分析和光谱方法进行表征，例如傅立叶变换红外光谱-原子吸收全反射率（FT-IR-ATR），1 H-核磁共振（1 H NMR）光谱和质谱。然后研究了在二甲基亚砜，二甲基甲酰胺，乙腈，乙酸，甲醇和氯仿中的溶剂变色性质和溶剂作用。此外，研究了有机和无机酸和碱对化合物吸收光谱的影响以及苯环键合基团的取代作用。
• Multicomponent synthesis of 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: a novel heterocyclic scaffold with antibacterial activity
  作者：Liliya V. Frolova、Indranil Malik、Pavel Y. Uglinskii、Snezna Rogelj、Alexander Kornienko、Igor V. Magedov

  DOI：10.1016/j.tetlet.2011.10.012

  日期：2011.12

  salicylic aldehydes and acetylacetic ester leading to the formation of novel 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones was discovered. The elucidation of the reaction scope revealed that 5-aminopyrazoles, 3-amino-1,2,4-triazoles and 6-aminouracil could be used as the heterocyclic amine component. Selected heterocyclic products were found to possess notable antibacterial activities.

  3-氨基吡唑-5-酮与取代水杨醛和乙酰乙酸酯的多组分反应导致形成新型2,3-二氢色基[4,3- d ]吡唑并[3,4- b ]吡啶-1,6-迪奥内斯被发现。反应范围的阐明表明5-氨基吡唑、3-氨基-1,2,4-三唑和6-氨基尿嘧啶可用作杂环胺组分。发现选定的杂环产品具有显着的抗菌活性。
• Alkylation of 1-phenyl-3,5-disubstituted pyrazoles with polyfluorinated aliphatic aldehydes
  作者：Yu.G Shermolovich、S.V Yemets

  DOI：10.1016/s0022-1139(99)00212-2

  日期：2000.1

  Polyfluorinated aliphatic aldehydes react with 1-phenyl-3-methylpyrazole-5-one, 1-phenyl-3-methyl-5-amino (N,N-dimethylaminomethylenamino)pyrazole and 1-phenyl-3-aminopyrazole-5-one at room temperature in the absence of catalyst with formation of 4-(1-hydroxypolyfluoroalkyl)pyrazoles. Dehydration of 4-(1-hydroxypolyfluoroalkyl)pyrazoles with morpholinosulfur trifluoride generates 4-polyfluoroalkylidenepyrazoles

  多氟脂族醛在室温下与1-苯基-3-甲基吡唑-5-酮，1-苯基-3-甲基-5-氨基（N，N-二甲基氨基甲基亚氨基）吡唑和1-苯基-3-氨基吡唑-5-酮反应在没有催化剂的情况下，在室温下形成4-（1-羟基多氟烷基）吡唑。用三氟化吗啉硫将4-（1-羟基多氟烷基）吡唑脱水，生成4-聚氟亚烷基吡唑，它们是有活性的亲二烯体，并与2,3-二甲基丁二烯和环戊二烯反应形成螺环吡唑衍生物。
• Colorant-Containing Curable Composition, Color Filter Using The Composition, and Method For Manufacturing The Same
  申请人：ARAKI Katsumi

  公开号：US20080021223A1

  公开（公告）日：2008-01-24

  The present invention provides a colorant-containing curable composition comprising a colorant, wherein the colorant contains a compound represented by the following Formula (I). In Formula (I), R 1 and R 2 each independently represent H, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. R 1 and R 2 may be formed into a heterocycle together with a jointly bonded nitrogen atom. R 3 represents a halogen atom, a trihalomethyl group, an alkoxy group, a nitro group, or an amino group. n represents an integer of 0 to 4. R 4 represents a halogen atom or a —SO 3 M group, in which M represents H, a cation of a metallic atom, or a cation consisting of a nitrogen-containing compound. m represents an integer of 0 to 5. The present invention further provides a color filter comprising the compound represented by Formula (I) and a method for manufacturing the color filter.

  本发明提供一种含色料的可固化组合物，其中色料包含以下式（I）所表示的化合物。在式（I）中，R1和R2各自独立地表示H、烷基、烯基、芳基或芳基烷基。R1和R2可以与共价键合的氮原子一起形成一个杂环。R3表示卤素原子、三卤甲基基团、烷氧基、硝基或氨基。n表示0到4的整数。R4表示卤素原子或—SO3M基团，其中M表示H、金属原子的阳离子或由含氮化合物组成的阳离子。m表示0到5的整数。本发明还提供一种包含式（I）所表示化合物的彩色滤光片以及一种制造该彩色滤光片的方法。
• AZO COMPOUND
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1739134A1

  公开（公告）日：2007-01-03

  The present invention provides an azo compound represented by the following Formula (I). In Formula (I), R1 and R2 respectively independently represent a hydrogen atom, an alkyl group having 1 to 21 carbon atoms, an alkenyl group having 2 to 21 carbon atoms, an aryl group having 6 to 21 carbon atoms or an aralkyl group having 7 to 21 carbon atoms, were R1 and R2 may form a hetero ring in combination with a nitrogen atom combined therewith. R3 represents a halogen atom, a trihalomethyl group, an alkoxy group having 1 to 21 carbon atoms, a nitro group or an amino group. R4 represents a halogen atom or a -SO3M group, where M represents a cation of a metal atom or a cation made of a nitrogen-containing compound. m denotes an integer from 0 to 5. n denotes an integer from 0 to 4.

  本发明提供了由下式（I）表示的偶氮化合物。式（I）中，R1 和 R2 分别独立地代表一个氢原子、一个具有 1 至 21 个碳原子的烷基、一个具有 2 至 21 个碳原子的烯基、一个具有 6 至 21 个碳原子的芳基或一个具有 7 至 21 个碳原子的芳烷基，其中 R1 和 R2 可与一个氮原子结合形成一个杂环。R3 代表卤素原子、三卤甲基、具有 1 至 21 个碳原子的烷氧基、硝基或氨基。R4 代表卤素原子或-SO3M 基团，其中 M 代表金属原子的阳离子或含氮化合物的阳离子。