Cdk4/6 Inhibitor IV | 359886-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Cdk4/6 Inhibitor IV
• 英文别名: CGP-082996；CINK4
• CAS: 359886-84-3
• 化学式: C₂₇H₃₂N₆O
• 分子量: 456.591
• InChiKey: YVXCDLCJCIDFHE-AFARHQOCSA-N

物化性质

• 沸点：
  755.4±70.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)
• 溶解度：
  乙醇中≤1mg/ml；DMSO中≤30mg/ml；二甲基甲酰胺中≤20mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  5.37
• 重原子数：
  34.0
• 可旋转键数：
  8.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  87.03
• 氢给体数：
  4.0
• 氢受体数：
  7.0

文献信息

• SYSTEM AND DEVICE FOR CHARACTERIZING CELLS
  申请人：Wirtz Denis

  公开号：US20150093779A1

  公开（公告）日：2015-04-02

  A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.
• US8934698B2
  申请人：——

  公开号：US8934698B2

  公开（公告）日：2015-01-13
• US9435738B2
  申请人：——

  公开号：US9435738B2

  公开（公告）日：2016-09-06
• [EN] SYSTEM AND DEVICE FOR CHARACTERIZING CELLS<br/>[FR] SYSTÈME ET DISPOSITIF POUR LA CARACTÉRISATION DE CELLULES
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2012178069A1

  公开（公告）日：2012-12-27

  A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.