N-(4-(oxazol-2-yl)benzyl)-N-(7-hydroxybicyclo[2.2.1]heptan-2-yl)-4-chlorobenzenesulfonamide | 1245651-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(oxazol-2-yl)benzyl)-N-(7-hydroxybicyclo[2.2.1]heptan-2-yl)-4-chlorobenzenesulfonamide
• 英文别名: 4-chloro-N-(7-hydroxy-2-bicyclo[2.2.1]heptanyl)-N-[[4-(1,3-oxazol-2-yl)phenyl]methyl]benzenesulfonamide
• CAS: 1245651-62-0
• 化学式: C₂₃H₂₃ClN₂O₄S
• 分子量: 458.966
• InChiKey: LZUPDOPJRGUHOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Alpha-(N-Benzenesulfonamido)Cycloalkyl Derivatives
  申请人：King Dalton

  公开号：US20100240708A1

  公开（公告）日：2010-09-23

  Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one or both of: (i) the functioning of a γ-secretase enzyme; or (ii) the production of β-amyloid. Such compounds may be beneficial in the treatment of Alzheimer's disease and other conditions. Representative compounds have the following formula I: wherein: A, R 1 , and R 2 are described herein.

  揭示了化合物、含有这些化合物的药物组合物、使用这些化合物的方法以及制备这些化合物的过程。更具体地，该公开涉及可能抑制以下一种或两种功能的α-(N-苯磺酰胺基)环烷基化合物：(i)γ-分泌酶酶的功能；或(ii)β-淀粉样蛋白的产生。这些化合物可能有助于治疗阿尔茨海默病和其他疾病。代表性化合物具有以下式I：其中：A、R1和R2如本文所述。
• ALPHA-(N-BENZENESULFONAMIDO)CYCLOALKYL DERIVATIVES
  申请人：Bristol-Myers Squibb Company

  公开号：EP2408756B1

  公开（公告）日：2013-05-15
• US7977362B2
  申请人：——

  公开号：US7977362B2

  公开（公告）日：2011-07-12
• [EN] ALPHA-(N-BENZENESULFONAMIDO)CYCLOALKYL DERIVATIVES<br/>[FR] DÉRIVÉS ALPHA-(N-BENZÈNESULFONAMIDO)CYCLOALKYLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010108067A1

  公开（公告）日：2010-09-23

  Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one or both of: (i) the functioning of a γ-secretase enzyme; or (ii) the production of -amyloid. Such compounds may be beneficial in the treatment of Alzheimer's disease and other conditions. Representative compounds have the following formula (I) wherein: A, R1, and R2 are described herein.