N-(4-(1H-pyrazol-1-yl)benzyl)-N-methyl-4-(3-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine | 1434058-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(1H-pyrazol-1-yl)benzyl)-N-methyl-4-(3-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine
• 英文别名: N-methyl-4-(5-methyl-1H-pyrazol-4-yl)-N-[(4-pyrazol-1-ylphenyl)methyl]pyrimidin-2-amine
• CAS: 1434058-59-9
• 化学式: C₁₉H₁₉N₇
• 分子量: 345.407
• InChiKey: DYDXUSVHBSJKKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  75.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compositions and Methods for Inhibition of TBL-1 Binding to Disease-Associated Molecules
  申请人：Vankayalapati Hariprasad M.

  公开号：US20130123281A1

  公开（公告）日：2013-05-16

  Compositions and methods which modulate diseases and disorders related to transducin β-like protein 1 (TBL1) activity, including but not limited to cancer, inflammation, and bone related diseases.

  调节与转导蛋白1（TBL1）活性相关的疾病和紊乱的组合物和方法，包括但不限于癌症、炎症和与骨骼相关的疾病。
• ANTI-B7-H4 ANTIBODIES AND IMMUNOCONJUGATES
  申请人：Genentech, Inc.

  公开号：US20140322129A1

  公开（公告）日：2014-10-30

  The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITION OF TBL-1 BINDING TO DISEASE-ASSOCIATED MOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR L'INHIBITION DE LA LIAISON DE LA TBL-1 À DES MOLÉCULES ASSOCIÉES À UNE MALADIE
  申请人：BETA CAT PHARMACEUTICALS LLC

  公开号：WO2013071232A1

  公开（公告）日：2013-05-16

  Compositions and methods which modulate diseases and disorders related to transducin β-like protein 1 (TBL1) activity, including but not limited to cancer, inflammation, and bone related diseases.