di-(11-hydroxylundecyl)telluride | 1580528-59-1

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: di-(11-hydroxylundecyl)telluride
• 英文别名: 11-(11-Hydroxyundecyltellanyl)undecan-1-ol；11-(11-hydroxyundecyltellanyl)undecan-1-ol
• CAS: 1580528-59-1
• 化学式: C₂₂H₄₆O₂Te
• 分子量: 470.206
• InChiKey: BXYWRBOGEZFVQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.53
• 重原子数：
  25
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  di-(11-hydroxylundecyl)telluride 、 cisplatin 以 氘代二甲亚砜 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Tellurium-Containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems

  摘要：

  Nanomaterials capable of achieving tunable cargo release kinetics are of significance in a fundamental sense and various biological or medical applications. We report a competitive coordination system based on a novel tellurium-containing polymer and its ligand-regulated release manners. Tellurium was introduced to water-soluble polymers for the first time as drug delivery vehicles. The coordination chemistry between platinum and tellurium was designed to enable the load of platinum-based drugs. Through the competitive coordination of biomolecules, the drugs could be released in a controlled manner. Furthermore, the release kinetics could be modulated by the competitive ligands involved due to their different coordination ability. This tellurium-containing polymer may enrich the family of delivery systems and provide a new platform for future biomedical nanotechnologies.

  DOI：

  10.1021/ja500939m
• 作为产物：
  描述：

  11-溴-1-十一醇 在 disodium telluride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以60%的产率得到di-(11-hydroxylundecyl)telluride
  参考文献：
  名称：

  Tellurium-Containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems

  摘要：

  Nanomaterials capable of achieving tunable cargo release kinetics are of significance in a fundamental sense and various biological or medical applications. We report a competitive coordination system based on a novel tellurium-containing polymer and its ligand-regulated release manners. Tellurium was introduced to water-soluble polymers for the first time as drug delivery vehicles. The coordination chemistry between platinum and tellurium was designed to enable the load of platinum-based drugs. Through the competitive coordination of biomolecules, the drugs could be released in a controlled manner. Furthermore, the release kinetics could be modulated by the competitive ligands involved due to their different coordination ability. This tellurium-containing polymer may enrich the family of delivery systems and provide a new platform for future biomedical nanotechnologies.

  DOI：

  10.1021/ja500939m

文献信息

• Tellurium-Containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems
  作者：Wei Cao、Yuwei Gu、Myriam Meineck、Tianyu Li、Huaping Xu

  DOI：10.1021/ja500939m

  日期：2014.4.2

  Nanomaterials capable of achieving tunable cargo release kinetics are of significance in a fundamental sense and various biological or medical applications. We report a competitive coordination system based on a novel tellurium-containing polymer and its ligand-regulated release manners. Tellurium was introduced to water-soluble polymers for the first time as drug delivery vehicles. The coordination chemistry between platinum and tellurium was designed to enable the load of platinum-based drugs. Through the competitive coordination of biomolecules, the drugs could be released in a controlled manner. Furthermore, the release kinetics could be modulated by the competitive ligands involved due to their different coordination ability. This tellurium-containing polymer may enrich the family of delivery systems and provide a new platform for future biomedical nanotechnologies.