(R)-3-[(R)-3-hydroxybutanoyloxy]butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate
• 英文别名: (3R)-3-[(3R)-3-hydroxybutanoyl]oxybutanoate
• 化学式: C8H13O5-
• 分子量: 189.19
• InChiKey: RILHUWWTCSDPAN-PHDIDXHHSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  86.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 、 水 生成 D-β-hydroxybutyrate 、 氢(+1)阳离子
  参考文献：
  名称：

  Roles of Poly(3-Hydroxybutyrate) Depolymerase and 3HB-Oligomer Hydrolase in Bacterial PHB Metabolism

  摘要：

  Many poly-3-hydroxybutyrate (PHB)-degrading enzymes have been studied. But biological roles of 3HB-oligomer hydrolases (3HBOHs) and how PHB depolymerases (PHBDPs) and 3HBOHs cooperate in PHB metabolism are not fully elucidated. In this study, several PHBDPs and 3HBOHs from three types of bacteria were purified, and their substrate specificity, kinetic properties, and degradation products were investigated. From the results, PHBDP and 3HBOH seemed to play a role in PHB metabolism in three types of bacteria, as follows: (A) In Ralstonia pickettii T1, an extracellular PHBDP degrades extracellular PHB to various-sized 3HB-oligomers, which an extracellular 3HBOH hydrolyzes to 3HB-monomers. (B) In Acidovorax sp. SA1, an extracellular PHBDP hydrolyzes extracellular PHB to small 3HB-oligomers (dimer and trimer), which an intracellular 3HBOH efficiently degrades to 3HB in the cell. (C) In Ralstonia eutropha H 16, an intracellular 3HBOH helps in the degradation of intracellular PHB inclusions by PHBDP.

  DOI：

  10.1007/s00284-003-4227-x

文献信息

• Delafield F.P.; Cooksey K.E.; Doudoroff M., J Biol Chem, 1965, 0021-9258, 4023-8
  作者：Delafield F.P.、Cooksey K.E.、Doudoroff M.

  DOI：——

  日期：——