[aP4443][Br] hydrobromide | 1155411-77-0

• 分子结构分类: 有机化合物 - 有机磷化合物 - 四烷基鏻化合物
• 英文名称: [aP4443][Br] hydrobromide
• 英文别名: (3-aminopropyl)tributylphosphonium bromide hydrobromide
• CAS: 1155411-77-0
• 化学式: BrH*Br*C₁₅H₃₅NP
• 分子量: 421.239
• InChiKey: RGNCXKHJDJXRFW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  19.0
• 可旋转键数：
  12.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.02
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  [aP4443][Br] hydrobromide 在 吡啶 、 4-二甲氨基吡啶 、 水 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 、 lithium hydroxide 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 71.0h， 生成 2'-TIPS-3'-[tributyl(3-(7-oxy-4,7-dioxoheptanamido)propyl)phosphonium bromde]uridine
  参考文献：
  名称：

  Ionic tags for synthesis of oligoribonucleotides

  摘要：

  该发明涉及寡核苷酸的化学合成，例如寡核糖核苷酸。在另一个方面，该发明涉及公式（II）化合物的制备过程以及这些化合物在寡核苷酸的化学合成中的使用，例如寡核糖核苷酸。该发明还涉及寡聚物的合成方法，包括但不限于寡肽、寡糖和寡核苷酸，特别是寡核糖核苷酸和寡脱氧核糖核苷酸，在溶液系统中，以及用于所述方法的离子标签连接剂。

  公开号：

  US09920084B2
• 作为产物：
  描述：

  三丁基膦 、 3-溴丙胺氢溴酸盐 以 乙腈 为溶剂， 以46 %的产率得到[aP4443][Br] hydrobromide
  参考文献：
  名称：

  [EN] TARGETED DELIVERY OF 1, 2, 4, 5-TETRAOXANE COMPOUNDS AND THEIR USES
  [FR] ADMINISTRATION CIBLÉE DE COMPOSÉS DE 1,2,4,5-TÉTRAOXANE ET LEURS UTILISATIONS

  摘要：

  1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.

  公开号：

  WO2022161490A1

文献信息

• Dual Amino-Functionalised Phosphonium Ionic Liquids for CO₂Capture
  作者：Yanqiang Zhang、Suojiang Zhang、Xingmei Lu、Qing Zhou、Wei Fan、XiangPing Zhang

  DOI：10.1002/chem.200801184

  日期：2009.3.9

  AbstractCO2 is locked up: Dual amino‐functionalised phosphonium ionic liquids (ILs; see figure) have been prepared. The ILs have excellent thermal properties, such as low glass transition temperatures and high thermal decomposition temperatures. The supported CO2 absorption of four of the ILs on porous SiO2 was found to approach one mol CO2 per mol IL, a factor of two greater than that reported before.magnified imageA series of 20 dual amino‐functionalised phosphonium ionic liquids, (3‐aminopropyl)tributylphosphonium amino acid salts ([aP4443][AA], in which [AA]−=[Ala]−, [Arg]−, [Asn]−, [Asp]−, [Cys]−, [Gln]−, [Glu]−, [Gly]−, [His]−, [Ile]−, [Leu]−, [Lys]−, [Met]−, [Phe]−, [Pro]−, [Ser]−, [Thr]−, [Trp]−, [Tyr]− and [Val]−), has been prepared. Their physicochemical properties, such as density, viscosity, glass transition and thermal decomposition temperatures and conductivity, have been determined. In particular, the [aP4443][AA] ionic liquids (ILs) have low glass transition temperatures ranging from −69.7 to −29.6 °C and high decomposition temperatures (all above 200 °C). The effects of the variation of the structure of [AA]− on the above physicochemical properties are discussed. Furthermore, the CO2 absorption of [aP4443][Gly], [aP4443][Ala], [aP4443][Val] and [aP4443][Leu], taken as examples, was investigated. It was found that the supported absorption of CO2 by the [aP4443][AA] ILs almost reaches equilibrium within 80 min, the chemical absorption of CO2 by the [aP4443][AA] ILs approaches 1 mol CO2 per mol ionic liquid (twice that reported before) and the [aP4443][AA] ILs can be repeatedly recycled for CO2 uptake.
• A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers
  作者：Melissa Millard、John D. Gallagher、Bogdan Z. Olenyuk、Nouri Neamati

  DOI：10.1021/jm4012438

  日期：2013.11.27

  Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents. Importantly, cancer cells have higher intrinsic mitochondrial membrane potential (Delta psi(mt),) than normal cells. Therefore, selectively targeting nitrogen mustards to cancer cell mitochondria based on Delta psi(mt), could overcome those limitations. Herein, we describe the design, synthesis, and evaluation of Mito-Chlor, a triphenylphosphonium derivative of the nitrogen mustard chlorambucil. We show that Mito-Chlor localizes to cancer cell mitochondria where it acts on mtDNA to arrest cell cycle and induce cell death, resulting in a 80-fold enhancement of cell kill in a panel of breast and pancreatic cancer cell lines that are insensitive to the parent drug. Significantly, Mito-Chlor delayed tumor progression in a mouse xenograft model of human pancreatic cancer. This is a first example of repurposing chlorambucil, a drug not used in breast and pancreatic cancer treatment, as a novel drug candidate for these diseases.