4-苄氧基苯甲酸酐 | 1486-49-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-苄氧基苯甲酸酐
• 英文名称: p-(benzyloxy)benzoic acid anhydride
• 英文别名: 4-benzyloxy-benzoic acid-anhydride；4-Benzyloxy-benzoesaeure-anhydrid；<4-Benzyloxy-benzoesaeure>-anhydrid；4-Benzyloxybenzoic acid anhydride；(4-phenylmethoxybenzoyl) 4-phenylmethoxybenzoate
• CAS: 1486-49-3
• 化学式: C₂₈H₂₂O₅
• 分子量: 438.48
• InChiKey: KVVRJYYXGYCCLY-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C
• 沸点：
  625.9±50.0 °C(Predicted)
• 密度：
  1.231±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  4-苄氧基苯甲酸酐 在 盐酸 、 sodium-<4-benzyloxy benzoate> 、 溶剂黄146 作用下， 生成 4',5-二羟基-7-甲氧基黄酮
  参考文献：
  名称：

  Tseng, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1935, vol. 55, p. 132,141; engl. Ref. S. 30, 35

  摘要：

  DOI：
• 作为产物：
  描述：

  4-苯甲氧基苯(甲)酰氯 在 吡啶 作用下， 生成 4-苄氧基苯甲酸酐
  参考文献：
  名称：

  摆锤蛋白的合成

  摘要：

  完整的摆锤蛋白合成，最终证明了该物质的拟议结构。

  DOI：

  10.1016/0040-4020(58)88011-4

文献信息

• Optically active compound and photosensitive resin composition
  申请人：——

  公开号：US20030211421A1

  公开（公告）日：2003-11-13

  A photoactive compound is used in combination with a photosensitizer, represented by the following formula (1): A −[( J ) m −( X-Pro )] n (1) wherein A represents a hydrophobic unit comprising at least one kind of hydrophobic groups selected from a hydrocarbon group and a heterocyclic group, J represents a connecting group, X-Pro represents a hydrophilic group protected by a protective group Pro which is removable by light exposure, m represents 0 or 1, and n represents an integer of not less than 1. The protective group Pro may be removable by light exposure in association with the photosensitizer (especially, a photo acid generator), or may be a hydrophobic protective group. The hydrophilic group may be a hydroxyl group or a carboxyl group. The photoactive compound has high sensitivity to a light source of short wavelength beams, for resist application, therefore, the photoactive compound is advantageously used for forming a pattern with high resolution.

  一种光活性化合物与光敏剂结合使用，由以下公式（1）表示： A −[( J ) m −( X-Pro )] n (1) 其中，A代表至少包括一种从烃基和杂环基中选择的疏水基的疏水单元，J代表连接基团，X-Pro代表由光照可去除的保护基团Pro保护的亲水基团，m代表0或1，n代表不少于1的整数。 保护基团Pro可以与光敏剂（特别是光酸发生剂）一起通过光照可去除，也可以是疏水保护基团。亲水基团可以是羟基或羧基。光活性化合物对短波长光源具有很高的敏感性，用于光刻应用，因此，该光活性化合物有利于形成具有高分辨率的图案。
• Synthesis of 5,8-dihydroxy-6,7-dimethoxyflavones and revised structures for some natural flavones
  作者：T Horie

  DOI：10.1016/0031-9422(95)00070-n

  日期：1995.7

  7-trimethoxyflavones were synthesized from 2′,5′-dihydroxy-3′,4′,6′-trimethoxyacetophenone by adapting the selective O -alkylation and dealkylation, and the differentiation between the flavones and their isomeric 6-hydroxyflavones was clarified by 1 H NMR and UV spectra. Four natural flavones proposed as 5,8-dihydroxy-6,7-dimethoxyflavones, must have other structures and three are shown to be the isomeric

  摘要 以 2',5'-二羟基-3',4',6'-三甲氧基苯乙酮为原料，合成了 6 个 5,8-二羟基-6,7-二甲氧基黄酮和 3 个 8-羟基-5,6,7-三甲氧基黄酮。选择性O-烷基化和脱烷基化，黄酮和它们的异构体6-羟基黄酮之间的区别通过 1 H NMR 和紫外光谱得到澄清。四种天然黄酮被提议为 5,8-二羟基-6,7-二甲氧基黄酮，必须具有其他结构，其中三种被证明是异构的 5,7-二羟基-6,8-二甲氧基黄酮。从 Ageratum conyzoides 中分离出的黄酮被正确识别为 8-hydroxy-5,6,7,3',4',5'-六甲氧基黄酮，但从蜡菊中分离出的黄酮的结构被修改为异构体 7 -羟基-5,6,8-三甲氧基黄酮。
• 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity
  作者：Nadine De Meyer、Achiel Haemers、Lallan Mishra、Hrishi Kesh Pandey、L. A. C. Pieters、Dirk A. Vanden Berghe、Arnold J. Vlietinck

  DOI：10.1021/jm00106a039

  日期：1991.2

  4'-Hydroxy-3-methoxyflavones are natural compounds with known antiviral activities against picornaviruses such as poliomyelitis and rhinoviruses. In order to establish a structure-activity relationship a series of analogues were synthesized, and their antiviral activities and cytotoxicities were compared with those of flavones from natural origin. The 4'-hydroxyl and 3-methoxyl groups, a substitution in the 5 position and a polysubstituted A ring appeared to be essential requirements for a high activity. The most interesting compound was 4',7-dihydroxy-3-methoxy-5,6-dimethylflavone possessing in vitro TI99 values of > 1000 and > 200 against poliovirus type 1 and rhinovirus type 15, respectively. This compound was also active against other rhinovirus serotypes (2, 9, 14, 29, 39, 41, 59, 63, 70, 85, and 89) tested, having MIC50 values ranging from 0.016 to 0.5-mu-g/mL. Finally in contrast to quercetin it showed to be not mutagenic in concentrations up to 2.5 mg in the Ames test.
• Horie, Tokunaru; Kawamura, Yasuhiko; Tsukayama, Masao, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 5, p. 1216 - 1220
  作者：Horie, Tokunaru、Kawamura, Yasuhiko、Tsukayama, Masao、Yoshizaki, Shiro

  DOI：——

  日期：——
• Kobayashi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 1
  作者：Kobayashi

  DOI：——

  日期：——