2,3-bis(hydroxymethyl)-6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene | 161359-58-6

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基萘木脂素
• 英文名称: 2,3-bis(hydroxymethyl)-6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene
• 英文别名: [3-Hydroxymethyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanol；[3-(hydroxymethyl)-6,7-dimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalen-2-yl]methanol
• CAS: 161359-58-6
• 化学式: C₂₃H₂₆O₇
• 分子量: 414.455
• InChiKey: NZKILVAZKDWRAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,3-bis(hydroxymethyl)-6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene 在 silver carbonate 作用下， 以 苯 为溶剂， 反应 3.0h， 以74%的产率得到6,7-Dimethoxy-4-(3,4,5-trimethoxy-phenyl)-3H-naphtho[2,3-c]furan-1-one
  参考文献：
  名称：

  1-Arylnaphthalene Lignan:  A Novel Scaffold for Type 5 Phosphodiesterase Inhibitor

  摘要：

  1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan series, in which 1-(3-bromo-4, 5-dimethoxyphenyl)-5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinylcarbonyl]-2-(methoxycarbonyl)naphthalene hydrochloride (27q) showed the most potent and specific inhibition (PDE5 inhibition IC50 = 6.2 nM, selectivity for PDE5 against PDE1, -2, -3, and -4 > 16 000). It is noteworthy that 27q has the best selectivities against PDE isoforms among PDE5 inhibitors so far reported. Compound 27q exhibited almost the same relaxant effects on rat aortic rings as sodium 1-[6-chloro-4-[(3,4-methylenedioxybenzyl)amino]quinazolin-2-yl]piperidine-4-carboxylate (35) (27q, EC50 = 0.10 mu M; 35, EC50 = 0.20 mu M) and was selected for further biological evaluation.

  DOI：

  10.1021/jm9807048
• 作为产物：
  描述：

  1-溴-2-(二甲氧基甲基)-4,5-二甲氧基苯 在 sodium hydroxide 、 正丁基锂 、 溶剂黄146 、 红铝 、 三氟乙酸 作用下， 以 甲苯 为溶剂， 反应 4.5h， 生成 2,3-bis(hydroxymethyl)-6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene
  参考文献：
  名称：

  1-Arylnaphthalene Lignan:  A Novel Scaffold for Type 5 Phosphodiesterase Inhibitor

  摘要：

  1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan series, in which 1-(3-bromo-4, 5-dimethoxyphenyl)-5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinylcarbonyl]-2-(methoxycarbonyl)naphthalene hydrochloride (27q) showed the most potent and specific inhibition (PDE5 inhibition IC50 = 6.2 nM, selectivity for PDE5 against PDE1, -2, -3, and -4 > 16 000). It is noteworthy that 27q has the best selectivities against PDE isoforms among PDE5 inhibitors so far reported. Compound 27q exhibited almost the same relaxant effects on rat aortic rings as sodium 1-[6-chloro-4-[(3,4-methylenedioxybenzyl)amino]quinazolin-2-yl]piperidine-4-carboxylate (35) (27q, EC50 = 0.10 mu M; 35, EC50 = 0.20 mu M) and was selected for further biological evaluation.

  DOI：

  10.1021/jm9807048

文献信息

• Novel Selective PDE IV Inhibitors as Antiasthmatic Agents. Synthesis and Biological Activities of a Series of 1-Aryl-2,3-bis(hydroxymethyl)naphthalene Lignans
  作者：Tameo Iwasaki、Kazuhiko Kondo、Tooru Kuroda、Yasunori Moritani、Shinsuke Yamagata、Masaki Sugiura、Hideo Kikkawa、Osamu Kaminuma、Katsuo Ikezawa

  DOI：10.1021/jm9509096

  日期：1996.1.1

  A series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans have been synthesized and evaluated for their ability to selectively inhibit PDE IV isolated from guinea pig. Replacement of the 1-phenyl ring by a pyridone ring led to marked improvement of their selectivity for PDE IV over PDE III. The compounds that were most potent and selective involved those bearing an N-alkylpyridone ring at C-1. These

  已经合成了一系列的1-芳基-2,3-双（羟甲基）萘木酚素，并对其选择性抑制豚鼠分离的PDE IV的能力进行了评估。1-吡啶环被吡啶酮环取代导致其对PDE IV的选择性比PDE III显着提高。最有效和最具选择性的化合物涉及在C-1处带有N-烷基吡啶酮环的化合物。这些化合物还显示出有效的抗痉挛活性，而不会引起豚鼠心率的显着变化。最有效的化合物是6,7-二乙氧基-2，3-双（羟甲基）-1- [1-（2-甲氧基乙基）-2-氧代-吡啶-4-基] nap hth alene（17f），ED50值在豚鼠中，组胺诱导的和抗原诱导的支气管收缩分别为0.08和2.3 mg / kg iv。
• 1-Arylnaphthalene Lignan:  A Novel Scaffold for Type 5 Phosphodiesterase Inhibitor
  作者：Tatsuzo Ukita、Yoshinori Nakamura、Akira Kubo、Yasuo Yamamoto、Masami Takahashi、Jun Kotera、Tomohiro Ikeo

  DOI：10.1021/jm9807048

  日期：1999.4.1

  1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan series, in which 1-(3-bromo-4, 5-dimethoxyphenyl)-5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinylcarbonyl]-2-(methoxycarbonyl)naphthalene hydrochloride (27q) showed the most potent and specific inhibition (PDE5 inhibition IC50 = 6.2 nM, selectivity for PDE5 against PDE1, -2, -3, and -4 > 16 000). It is noteworthy that 27q has the best selectivities against PDE isoforms among PDE5 inhibitors so far reported. Compound 27q exhibited almost the same relaxant effects on rat aortic rings as sodium 1-[6-chloro-4-[(3,4-methylenedioxybenzyl)amino]quinazolin-2-yl]piperidine-4-carboxylate (35) (27q, EC50 = 0.10 mu M; 35, EC50 = 0.20 mu M) and was selected for further biological evaluation.