Ac-ΔPhe-(S)-Leu-OH | 57744-46-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-ΔPhe-(S)-Leu-OH
• 英文别名: N-Ac-Δ-Phe-Leu；N-(α-Acetylaminocinnamoyl)-leucin；N-Acetyldehydrophenylalanyl-L-leucin；N-(α-acetylamino-cinnamoyl)-L-leucine；N-(α-Acetamino-cinnamoyl)-L-leucin；(2S)-2-[(2-acetamido-3-phenylprop-2-enoyl)amino]-4-methylpentanoic acid
• CAS: 57744-46-4
• 化学式: C₁₇H₂₂N₂O₄
• 分子量: 318.373
• InChiKey: XJYDCXKKCZHEEP-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ac-ΔPhe-(S)-Leu-OH 在 {Rh((+)-diop)Cl} 氢气 作用下， 以 甲醇 、 乙醚 为溶剂， 20.0 ℃ 、100.0 kPa 条件下， 生成 Ac-(S)-Phe-(S)-Leu-OMe
  参考文献：
  名称：

  Asymmetric homogeneous reduction of dehydropeptides

  摘要：

  DOI：

  10.1016/s0040-4020(01)87539-6
• 作为产物：
  描述：

  (L)-leucine sodium salt 、 (Z)-4-亚苄基-2-甲基噁唑-5(4h)-酮 以94%的产率得到Ac-ΔPhe-(S)-Leu-OH
  参考文献：
  名称：

  Asymmetric homogeneous reduction of dehydropeptides

  摘要：

  DOI：

  10.1016/s0040-4020(01)87539-6

文献信息

• Behrens; Doherty; Bergmann, Journal of Biological Chemistry, 1940, vol. 136, p. 61,64
  作者：Behrens、Doherty、Bergmann

  DOI：——

  日期：——
• Asymmetric hydrogenation ofN-acetyldehydrodipeptide complexes with Mg(II) and Ca(II) ions
  作者：I. N. Lisichkina、A. I. Vinogradova、N. B. Sukhorukova、E. V. Tselyapina、M. B. Saporovskaya、V. M. Belikov

  DOI：10.1007/bf00698456

  日期：1993.3

  N-Ac-DELTA-Phe-AA form labile complexes with Mg(II) ions. Potentiometric titration data show that the carboxyl group of the dehydrodipeptide in them scarcely participates in complexation, unlike the complexes with Ca(II) ions, The hydrogenation of these complexes over Pd/C occurs asymmetrically, the diastereomeric excess being as high as 58%.
• Diastereoselective hydrogenation of N-acetyldehydrodipeptides
  作者：V. K. Latov、A. I. Vinogradova、M. B. Saporovskaya、V. M. Belikov

  DOI：10.1007/bf00949793

  日期：1982.3
• Relation between type a behavior pattern and the extent of coronary atherosclerosis in Japanese women
  作者：Kouichi Yoshimasu、Masakazu Washio、Shoji Tokunaga、Keitaro Tanaka、Ying Liu、Hiroko Kodama、Hidekazu Arai、Samon Koyanagi、Koji Hiyamuta、Yoshitaka Doi、Tomoki Kawano、Osamu Nakagaki、Kazuyuki Takada、Shizuka Sasazuki、Takanobu Nii、Kazuyuki Shirai、Munehito Ideishi、Kikuo Arakawa、Masahiro Mohri、Akira Takeshita

  DOI：10.1207/s15327558ijbm0902_01

  日期：2002.6

  This study examined the relation of Type A behavior pattern and its components to angiographically documented coronary atherosclerosis in 198 Japanese women. A questionnaire-based interview elicited psychosocial and other factors. Type A behavior pattern was measured by 12 questions. Significant coronary stenosis was defined when a 75% or greater luminal narrowing occurred at one or more major coronary arteries or 50% or greater narrowing occurred at the left main artery. Gensini's score also was calculated. Logistic regression analysis was used to calculate odds ratios and 95% confidence intervals with adjustment for traditional coronary risk factors and the presence of a job. Global Type A behavior pattern showed no material association with the severity of coronary atherosclerosis assessed by both Gensini's score and the presence of significant coronary stenosis. However, its subcomponents, enthusiasm and competitiveness, were positively related to the severity of coronary atherosclerosis, whereas self-confidence and perfectionism were negatively related. These findings suggest overall a null association between global Type A and coronary atherosclerosis as well as the presence of toxic or beneficial components of Type A behaviors in Japanese women.