N-adamantan-1-yl acrylamide | 105077-42-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-adamantan-1-yl acrylamide
• 英文别名: N-(adamantan-2-yl)prop-2-enamide；N-(2-adamantyl)prop-2-enamide
• CAS: 105077-42-7
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: XPRPLYWRNZUUHW-UHFFFAOYSA-N

物化性质

• 沸点：
  376.1±15.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三乙胺 、 2,6-二叔丁基-4-巯基苯酚 、 N-adamantan-1-yl acrylamide 在 三乙胺 、 silica 、 Ethyl acetate ether hexane 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-N-tricyclo[3.3.1.13,7]dec-2-yl propanamide
  参考文献：
  名称：

  Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides

  摘要：

  本发明的化合物是由以下式子表示的双环、三环、氮杂双环和氮杂三环酰胺：##STR1## 其中：R.sub.1和R.sub.2是以下组成的同类或异类成员：卤素、苯基、取代苯基和一个##STR2##组，其中n、m和p独立地是1至8的整数，但n+m+p小于或等于10；X是硫、亚砜或磺酰基；Alk是直链或支链低碳链；R.sub.3选自以下组成的群体：双环烷基氨基、三环烷基氨基、氮杂双环烷基、氮杂三环烷基、氮杂双环烷基氨基、氮杂三环烷基氨基或二环烷基氨基。这些化合物可用作抗炎和抗过敏剂。

  公开号：

  US05019597A1
• 作为产物：
  描述：

  2-氨基金刚烷 、 丙烯酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到N-adamantan-1-yl acrylamide
  参考文献：
  名称：

  Highly Elastic Supramolecular Hydrogels Using Host–Guest Inclusion Complexes with Cyclodextrins

  摘要：

  Supramolecular hydrogels, which are cross-linked via host guest interactions, show high-performance physical properties, such as elasticity and toughness. Herein we prepare a supramolecular hydrogel without chemical crosslinker. The supramolecular hydrogel was prepared by polymerization of the inclusion complexes between beta-cyclodextrin acrylamide and adamantane acrylamide monomers. The beta-cyclodextrin adamantane gel (beta CD Ad gel) shows a high stretching property (990%). The initial strain (0%) is restored in several minutes for a beta CD Ad gel stretched to 180% of the initial strain without altering the physical history. However, chemically cross-linked poly(acrylamide) does not show the reversible stretching property. These results indicate that host guest interaction inside the supramolecular hydrogel plays an important role in the shape recovery properties.

  DOI：

  10.1021/ma400695p

文献信息

• Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio
  申请人：G. D. Searle & Co.

  公开号：US05157053A1

  公开（公告）日：1992-10-20

  The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; x is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group-consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, aszabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino, The compounds are useful as anti-inflammatory and anti-allergy agents.

  本发明的化合物是由下式表示的双环、三环、氮杂双环和氮杂三环酰胺：##STR1## 其中：R.sub.1和R.sub.2是卤素、苯基、取代苯基和##STR2##基团中相同或不同的成员，其中n、m和p是独立的1至8的整数，前提是n+m+p等于或小于10；x是硫、亚硫酰或磺酰基；Alk是直链或支链低级烷基；R.sub.3选自以下群体：双环烷基氨基、三环烷基氨基、氮杂双环烷基、氮杂三环烷基、aszabicycloalkylamino、azatricycloalkylamino或二环烷基氨基。这些化合物可用作抗炎和抗过敏剂。
• Azabicycloalkyl and azatricycloalkyl amides
  申请人：G. D. Searle & Co.

  公开号：US05198435A1

  公开（公告）日：1993-03-30

  The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided than n+m+p is equal to or less than 10; x is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.

  本发明的化合物是由下式表示的双环、三环、氮杂双环和氮杂三环酰胺：##STR1## 其中：R.sub.1和R.sub.2是卤素、苯基、取代苯基和一个##STR2##基团的相同或不同成员，其中n、m和p是独立的1到8的整数，前提是n+m+p等于或小于10；x是硫、亚砜或磺酰基；Alk是直链或支链低碳链；R.sub.3选自自行车烷基氨基、三自行车烷基氨基、氮杂自行车烷基、氮杂三环烷基、氮杂自行车烷基氨基、氮杂三环烷基氨基或二自行车烷基氨基的群。这些化合物可用作抗炎和抗过敏剂。
• Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides
  申请人：G. D. Searle & Co.

  公开号：US05019597A1

  公开（公告）日：1991-05-28

  The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.

  本发明的化合物是由以下式子表示的双环、三环、氮杂双环和氮杂三环酰胺：##STR1## 其中：R.sub.1和R.sub.2是以下组成的同类或异类成员：卤素、苯基、取代苯基和一个##STR2##组，其中n、m和p独立地是1至8的整数，但n+m+p小于或等于10；X是硫、亚砜或磺酰基；Alk是直链或支链低碳链；R.sub.3选自以下组成的群体：双环烷基氨基、三环烷基氨基、氮杂双环烷基、氮杂三环烷基、氮杂双环烷基氨基、氮杂三环烷基氨基或二环烷基氨基。这些化合物可用作抗炎和抗过敏剂。
• Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides
  申请人：G.D. Searle & Co.

  公开号：EP0190684A2

  公开（公告）日：1986-08-13

  The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: wherein: R, and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a group wherein n, m and p are independently an integer of from 1 to 8 provided that n + m + p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R3 is selected from the group consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.

  本发明的化合物为双环、三环、氮杂双环和氮杂环酰胺，由式表示： 其中R、和 R2 是卤代、苯基、取代苯基和一个基团组成的组中相同或不同的成员 其中 n、m 和 p 独立地为 1 至 8 的整数，条件是 n + m + p 等于或小于 10；X 为硫代、亚磺酰基或磺酰基；Alk 为直链或支链低级亚烷基；R3 选自由双环烷基氨基、三环烷基氨基、氮杂环烷基、氮杂环烷基、氮杂环烷基氨基、氮杂环烷基氨基或二环烷基氨基组成的组。这些化合物可用作抗炎剂和抗过敏剂。
• Process for producing aqueous ink for inkjet printing
  申请人：KAO CORPORATION

  公开号：EP0857766A1

  公开（公告）日：1998-08-12

  A process for producing an aqueous ink for inkjet printing capable of giving an elevated print density of printed matters, being improved in fixability to the material to be printed, water resistance and improved storage stability and scarcely scorching onto a printer head. This process comprises dissolving a salt-forming group-having polymer and a hydrophobic dye in a water-insoluble organic solvent to obtain a solution, adding water and a neutralizing agent optionally together with a surfactant to the solution to ionize the salt-forming group of the polymer, emulsifying the resulting mixture, and removing out the solvent from the emulsion to obtain an ink containing an aqueous dispersion of the polymer particles in which the dye has been encompassed.

  一种用于喷墨打印的水性墨水的生产工艺，这种墨水能够提高打印物的打印密度，改善对打印材料的固定性、耐水性和贮存稳定性，并且在打印头上几乎不会焦化。该工艺包括：将含盐基团的聚合物和疏水性染料溶解在不溶于水的有机溶剂中，得到溶液；向溶液中加入水和中和剂（可选择与表面活性剂一起加入），使聚合物的含盐基团电离；乳化得到的混合物；从乳液中除去溶剂，得到含有聚合物颗粒水性分散体的墨水，染料已被包在其中。