2-[2-hydroxy-4-(4-methoxybenzyloxy)phenyl]-5-hydroxy-8,8-dimethyl-3-(3-methyl-but-2-enyl)-pyrano[2,3-f]chromen-4-one | 1216959-11-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-[2-hydroxy-4-(4-methoxybenzyloxy)phenyl]-5-hydroxy-8,8-dimethyl-3-(3-methyl-but-2-enyl)-pyrano[2,3-f]chromen-4-one
• CAS: 1216959-11-3
• 化学式: C₃₃H₃₂O₇
• 分子量: 540.613
• InChiKey: HIVFDVXNYXRGJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.15
• 重原子数：
  40.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  98.36
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  在 硫代乙氧基锂 、 氯化铵 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 2-[2-hydroxy-4-(4-methoxybenzyloxy)phenyl]-5-hydroxy-8,8-dimethyl-3-(3-methyl-but-2-enyl)-pyrano[2,3-f]chromen-4-one
  参考文献：
  名称：

  The synthesis of morusin as a potent antitumor agent

  摘要：

  Morusin. which call be isolated from Chinese herbal medicine. is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described Consequently this strategy provided a concise route 10 synthesize the morusin analogues as well Further biological studies of morusin. it exhibited strong antitumor effects with IC(50) similar to 3 0 mu M oil three cancel cells (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.002