2-Bromo-1-(5-bromo-thiophen-2-yl)-ethanone oxime | 344746-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-Bromo-1-(5-bromo-thiophen-2-yl)-ethanone oxime
• 英文别名: N-[2-bromo-1-(5-bromothiophen-2-yl)ethylidene]hydroxylamine
• CAS: 344746-44-7
• 化学式: C₆H₅Br₂NOS
• 分子量: 298.986
• InChiKey: VQIXDNQEQJPLKA-UHFFFAOYSA-N

物化性质

• 沸点：
  359.3±37.0 °C(Predicted)
• 密度：
  2.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.08
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-Bromo-1-(5-bromo-thiophen-2-yl)-ethanone oxime 、 环丙沙星 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones

  摘要：

  A series of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[2-(5-bromothiophen-2-yl)-2-oximinoethyl]derivatives of piperazinyl quinolones were synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. Some of these derivatives exhibit comparable or better activity against Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, than ciprofloxacin, norfloxacin and enoxacine as reference drugs. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.005
• 作为产物：
  描述：

  2-乙酰基-5-溴噻吩 在 盐酸羟胺 、 溴 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 2-Bromo-1-(5-bromo-thiophen-2-yl)-ethanone oxime
  参考文献：
  名称：

  Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones

  摘要：

  A series of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[2-(5-bromothiophen-2-yl)-2-oximinoethyl]derivatives of piperazinyl quinolones were synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. Some of these derivatives exhibit comparable or better activity against Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, than ciprofloxacin, norfloxacin and enoxacine as reference drugs. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.005