N-butyl-4,5-bis(p-formylphenyl)-1,8-naphthalimide | 1092100-10-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: N-butyl-4,5-bis(p-formylphenyl)-1,8-naphthalimide
• 英文别名: 4-[2-Butyl-7-(4-formylphenyl)-1,3-dioxobenzo[de]isoquinolin-6-yl]benzaldehyde
• CAS: 1092100-10-1
• 化学式: C₃₀H₂₃NO₄
• 分子量: 461.517
• InChiKey: QATHJRCLLQQOME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  71.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-bromo-5-iodo-N-butyl-1,8-naphthalic imide 、 4-甲酰基苯硼酸 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以90%的产率得到N-butyl-4,5-bis(p-formylphenyl)-1,8-naphthalimide
  参考文献：
  名称：

  Highly selective fluorescent chemosensor with red shift for cysteine in buffer solution and its bioimage: symmetrical naphthalimide aldehyde

  摘要：

  A new fluorescent probe 1. N-butyl-4, 5-(p-aldehyde)phenyl-1,8-naphthalimide, was designed and synthesized for the determination of the cysteine (Cys). Upon addition of Cys, the emission of 1 was enhanced with about 25 nm red-shift in the emission maximum (from 455 to 480 nm), accompanied with the fluorescent color change from blue to cyan, which was attributed to the reaction of the aldehyde groups in 1 with cysteine to form very stable thiazolidines derivative. Compound 1 was highly selective for cysteine detection without the interference of other amino acids and can be used for bioimaging of Cys. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2008.09.021