1-(5-O-para-monomethoxytrityl-2,3-dideoxy-epimino-α-D-ribofuranosyl)thymine | 153322-17-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-(5-O-para-monomethoxytrityl-2,3-dideoxy-epimino-α-D-ribofuranosyl)thymine
• CAS: 153322-17-9
• 化学式: C₃₀H₂₉N₃O₅
• 分子量: 511.577
• InChiKey: MZTGCILYZQBKJP-LHWXFDGDSA-N

物化性质

• 密度：
  1.273±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  38.0
• 可旋转键数：
  8.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  104.49
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1-(5-O-para-monomethoxytrityl-2,3-dideoxy-epimino-α-D-ribofuranosyl)thymine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以100%的产率得到1-<(2,3-dideoxy-2,3-epimino)-α-D-ribofuranosyl>thymine
  参考文献：
  名称：

  Synthesis of Some New Nucleoside Analogues as Potential Antiviral Agents

  摘要：

  A novel series of pyrimidine nucleoside analogues was synthesized. 2,3-Dideoxy-2,3-anhydro-beta-D-lyxofuranose was opened by sodium azide to give the corresponding azido compound, which was reduced by lithium aluminium hydride to lead to 2,3-dideoxy-2,3-epimino-beta-D-ribofuranose. Pyrimidine bases were glycosylated with this synthon to give potential antiviral molecules : 1-(2,3-dideoxy-2,3-epimino-beta-D-ribofuranosyl)pyrimidines.

  DOI：

  10.1080/07328319308018562
• 作为产物：
  描述：

  胸腺嘧啶 在 三甲基氯硅烷 、 叔丁基二甲硅基三氟甲磺酸酯 作用下， 以 乙腈 为溶剂， 生成 1-(5-O-para-monomethoxytrityl-2,3-dideoxy-epimino-α-D-ribofuranosyl)thymine
  参考文献：
  名称：

  Synthesis of Some New Nucleoside Analogues as Potential Antiviral Agents

  摘要：

  A novel series of pyrimidine nucleoside analogues was synthesized. 2,3-Dideoxy-2,3-anhydro-beta-D-lyxofuranose was opened by sodium azide to give the corresponding azido compound, which was reduced by lithium aluminium hydride to lead to 2,3-dideoxy-2,3-epimino-beta-D-ribofuranose. Pyrimidine bases were glycosylated with this synthon to give potential antiviral molecules : 1-(2,3-dideoxy-2,3-epimino-beta-D-ribofuranosyl)pyrimidines.

  DOI：

  10.1080/07328319308018562