(R)-2-amino-1-(2-hydroxybenzamide)propane | 1334305-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-amino-1-(2-hydroxybenzamide)propane
• 英文别名: N-[(2R)-2-aminopropyl]-2-hydroxybenzamide
• CAS: 1334305-20-2
• 化学式: C₁₀H₁₄N₂O₂
• 分子量: 194.233
• InChiKey: BEGUHLDXLOAZPY-SSDOTTSWSA-N

物化性质

• 沸点：
  400.2±30.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-2-amino-1-(2-hydroxybenzamide)propane 、 potassium tert-butylate 、 cobalt(II) diacetate tetrahydrate 生成 K[Co(R-2-amino-1-(2-hydroxybenzamide)propane-2H)₂]
  参考文献：
  名称：

  Hydrogen-bonding interactions, geometrical selectivity and spectroscopic properties of cobalt(III) complexes with unsymmetrical tridentate amine-amidato-phenolato type ligands

  摘要：

  Four cobalt(III) complexes with the formula of [Co(Ln)(2)] bearing tridentate amine-amidato-phenolato-type ligands (Ln: n = 1-4) were synthesized. All of the complexes were characterized by H-1 NMR spectroscopy and X-ray analysis. The geometrical selectivity was found to depend on the flexibility of the amine-amidato chelate in combination with the planar 2-oxybenzamido 6-membered chelate; that is, the amine-amidato 5-membered chelate took the mer-type geometry, and the 6-membered chelate took the fac-type geometry. In most of the mer-type complexes, intermolecular double hydrogen bonds via amidato(O) and amino group were selectively formed between their enantiomeric pairs of mononuclear complexes. In the case of two chiral ligands {L2(2) = 2-amino-1-(2-oxybenzamido) propane; L3(2) = trans-1-amino-2-(2-oxybenzamido)cyclohexane}, [Co(L3)(2)] showed diastereoselectivity while [Co(L2)(2)] did not. Furthermore, PPh4[Co(L1)(2)] (L1(2) = 2-amino-1-(2-oxybenzamido)-2-methylpropane) showed an apparent solvatochromic behavior in several solvents. Although the molecular structures of [Co(L2 or L3)(2)] are quite similar to that of [Co(L1)(2)] , these complexes did not exhibit such a solvatochromic behavior. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.01.011
• 作为产物：
  描述：

  (R)-1,2-diaminopropane 、 水杨酸苯酯 以 异丙醇 为溶剂， 生成 (R)-2-amino-1-(2-hydroxybenzamide)propane
  参考文献：
  名称：

  Hydrogen-bonding interactions, geometrical selectivity and spectroscopic properties of cobalt(III) complexes with unsymmetrical tridentate amine-amidato-phenolato type ligands

  摘要：

  Four cobalt(III) complexes with the formula of [Co(Ln)(2)] bearing tridentate amine-amidato-phenolato-type ligands (Ln: n = 1-4) were synthesized. All of the complexes were characterized by H-1 NMR spectroscopy and X-ray analysis. The geometrical selectivity was found to depend on the flexibility of the amine-amidato chelate in combination with the planar 2-oxybenzamido 6-membered chelate; that is, the amine-amidato 5-membered chelate took the mer-type geometry, and the 6-membered chelate took the fac-type geometry. In most of the mer-type complexes, intermolecular double hydrogen bonds via amidato(O) and amino group were selectively formed between their enantiomeric pairs of mononuclear complexes. In the case of two chiral ligands {L2(2) = 2-amino-1-(2-oxybenzamido) propane; L3(2) = trans-1-amino-2-(2-oxybenzamido)cyclohexane}, [Co(L3)(2)] showed diastereoselectivity while [Co(L2)(2)] did not. Furthermore, PPh4[Co(L1)(2)] (L1(2) = 2-amino-1-(2-oxybenzamido)-2-methylpropane) showed an apparent solvatochromic behavior in several solvents. Although the molecular structures of [Co(L2 or L3)(2)] are quite similar to that of [Co(L1)(2)] , these complexes did not exhibit such a solvatochromic behavior. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.01.011

文献信息

• Preparation, structures and properties of manganese complexes containing amine–(amido or amidato)–phenolato type ligands
  作者：Ryoji Mitsuhashi、Rina Ogawa、Ryuta Ishikawa、Takayoshi Suzuki、Yukinari Sunatsuki、Satoshi Kawata

  DOI：10.1016/j.ica.2016.03.036

  日期：2016.6

  e)2] (2 or 4), were isolated and their crystal structures were determined. There was a weak antiferromagnetic interaction between two axially distorted MnIII centers in 2. Also, with the ligand of (L2Me2)2− a mononuclear manganese(IV) complex, [Mn(L2Me2)2]·DMF (3·DMF) was obtained. In the crystal of 3·DMF a heterochiral dimerization via the intermolecular double hydrogen-bonds was observed. In the

  摘要2-羟基-N-（n-氨基烷基）苯甲酰胺的络合物，其中n-氨基烷基取代基是2-氨基-2-甲基丙基（H2L2Me2），（R）-2-氨基丙基（R）-H2L2Me}和3-检查了氨基丙基（H2L3）与氯化锰（II）或高氯酸盐的关系。使用2-氨基丙基衍生物，带有双阴离子配体[Mn（L2Me2或（R）-L2Me）（MeOH）} 2（μ-OMe）2]的双核甲基氧化桥连的锰（III）配合物（2或4） ，分离，并确定其晶体结构。在2中的两个轴向变形的MnIII中心之间存在弱的反铁磁相互作用。而且，通过（L2Me2）2-的配体-单核锰（IV）配合物，获得了[Mn（L2Me2）2]·DMF（3·DMF） 。在3·DMF的晶体中，观察到经由分子间双氢键的异手性二聚。在与H2L3反应的情况下，提供了单核锰（III）配合物[Mn（H2L3'）2CL2] Cl（6）和[Mn（H2L3'）2（MeOH）2] CL2