2-Propanol, 1-((1,1-dimethylethyl)amino)-3-(4-(4-(trifluoromethyl)-1H-imidazol-2-yl)phenoxy)- | 60963-77-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-(4-(4-(trifluoromethyl)-1H-imidazol-2-yl)phenoxy)-
• 英文别名: 1-(tert-butylamino)-3-[4-[5-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propan-2-ol
• CAS: 60963-77-1
• 化学式: C₁₇H₂₂F₃N₃O₂
• 分子量: 357.37
• InChiKey: OHUGUDLAWZZRCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-[3-(2,3-Epoxypropoxy)-phenyl]-4-trifluoromethylimidazole 生成 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-(4-(4-(trifluoromethyl)-1H-imidazol-2-yl)phenoxy)-
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted
  申请人：Merck & Co., Inc.

  公开号：US04199580A1

  公开（公告）日：1980-04-22

  Novel 3-amino-2-OR-propoxy-tetrahydronaphthyl or indanyl substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明揭示了3-氨基-2-OR-丙氧基-四氢萘基或印安基取代咪唑的方法及其制备方法。这些咪唑及其盐表现出药理活性，包括降压活性和β-肾上腺素能阻滞活性。
• 3-Amino-2-hydroxypropoxyaryl imidazole derivatives
  申请人：Merck & Co., Inc.

  公开号：US04440774A1

  公开（公告）日：1984-04-03

  Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明揭示了式子##STR1##的新型取代咪唑衍生物及其制备方法。这些咪唑衍生物及其盐具有药理活性，包括抗高血压活性和β-肾上腺素能阻滞活性。
• .beta.-Adrenergic 2-[4-(3-amino-2-hydroxypropoxy)phenyl]imidazoles
  申请人：Merck & Co., Inc.

  公开号：US04567276A1

  公开（公告）日：1986-01-28

  Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明揭示了一种代替咪唑的新型咪唑化合物及其制备方法。这些咪唑化合物及其盐具有药理活性，包括抗高血压活性和β-肾上腺素能阻滞活性。
• .beta.-blocking substituted imidazoles
  申请人：Merck & Co., Inc.

  公开号：US04853383A1

  公开（公告）日：1989-08-01

  Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明揭示了一种新型替代咪唑并其制备方法。这些咪唑及其盐具有药理活性，包括抗高血压活性和β-肾上腺素能阻滞活性。
• 3-Amino-2-OR-propoxyaryl substituted imidazoles
  申请人：Merck & Co., Inc.

  公开号：US04134983A1

  公开（公告）日：1979-01-16

  Novel 3-amino-2-OR-propoxyaryl substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明公开了一种3-氨基-2-OR-丙氧基芳基取代咪唑及其制备方法。这些咪唑及其盐具有药理活性，包括降压活性和β-肾上腺素能阻滞活性。