[(tin(IV)(nBu)2(2-(9H-carbazol-9-yl)acetate))2O]2 | 1265637-28-2

• 英文名称: [(tin(IV)(nBu)2(2-(9H-carbazol-9-yl)acetate))2O]2
• CAS: 1265637-28-2
• 化学式: C₈₈H₁₁₂N₄O₁₀Sn₄
• 分子量: 1860.72
• InChiKey: VMCOMFLBBWBVMO-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  9-咔唑乙酸 、 二正丁基氧化锡 以 苯 为溶剂， 以75%的产率得到[(tin(IV)(nBu)2(2-(9H-carbazol-9-yl)acetate))2O]2
  参考文献：
  名称：

  Synthesis, characterization and in vitro antitumor activity of three organotin(IV) complexes with carbazole ligand

  摘要：

  Three novel organotin(IV) complexes with 2-(9H-carbazol-9-yl) acetic acid (HL), of the formulae {[nBu(2)S-nOL](2)O}(2) (1), [nBuSn(O)OL](6) (2) and [nBu(3)SnOL](6) (3) were prepared. All compounds were characterized by X-ray crystallography, confirming that complex (1) is tetranuclear one with ladder framework, complex (2) is a hexanuclear organotin(IV) complex with drum structure and complex (3) is a macrocycle with 24-membered stannoxane ring. Furthermore, all complexes were tested in vitro for their cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2). Complex (1) displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations. (C) 2010 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.09.024