acetic acid undec-10-enoic acid-anhydride | 18698-53-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid undec-10-enoic acid-anhydride
• 英文别名: Essigsaeure-undec-10-ensaeure-anhydrid；Acetyl undec-10-enoate
• CAS: 18698-53-8
• 化学式: C₁₃H₂₂O₃
• 分子量: 226.316
• InChiKey: HVMALXAVKHRRDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙烯酮 、 2-十一烯酸 在 乙醚 作用下， 生成 acetic acid undec-10-enoic acid-anhydride
  参考文献：
  名称：

  Acetylation of Monocarboxylic Acids with Ketene

  摘要：

  DOI：

  10.1021/ja01620a060

文献信息

• [EN] CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING THEM<br/>[FR] DÉRIVÉS DE POLYSACCHARIDE AYANT SUBI UNE MÉTHATHÈSE CROISÉE ET PROCÉDÉS DE PRÉPARATION DE CEUX-CI
  申请人：VIRGINIA TECH INTELL PROP

  公开号：WO2015048408A1

  公开（公告）日：2015-04-02

  Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.

  本文描述了一种用于多糖与一个或多个烯烃末端侧链进行交叉交换反应的方法以及交叉交换产物。在一个示例实施例中，描述了一种通过烯烃交叉交换合成纤维素ω-羧酯的方法。反应条件相对温和，烯烃取代的多糖和适当的单体烯烃伙伴似乎遵循Grubbs规则，如本文所述。这些化合物和方法可能对结构-性能研究有用，特别是那些旨在开发用于药物传递的聚合物，如控释药物传递系统、控释涂层、增加药物生物利用度以及在胃肠道中维持药物超饱和度。
• Cross-metathesized polysaccharide derivatives and processes for preparing them
  申请人：Edgar Kevin J.

  公开号：US10738134B2

  公开（公告）日：2020-08-11

  Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.

  本发明描述了具有一个或多个烯烃末端侧链的多糖的交联聚合以及交联聚合产物的方法。在一个示例性实施方案中，描述了一种通过烯烃交叉甲基化合成纤维素ω-羧酸酯的方法。反应条件相对温和，烯烃取代的多糖和适当的单体烯烃伙伴似乎遵循本文总结的格拉布斯规则。这些化合物和方法可用于结构-性质研究，特别是那些旨在开发药物输送用聚合物的研究，例如用于控释药物输送系统、控释涂层、提高药物的生物利用度以及维持药物在消化道中的过饱和度。
• Polysaccharide derivatives and cross-metathesis processes for preparing them
  申请人：Edgar Kevin J.

  公开号：US10851179B2

  公开（公告）日：2020-12-01

  Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.

  本发明描述了具有一个或多个烯烃末端侧链的多糖交联聚合以及交联聚合产物的方法。在一个示例性实施方案中，描述了一种通过烯烃与丙烯酸酯的交叉甲基化反应合成纤维素ω-羧酸酯的方法。反应条件相对温和，烯烃取代的多糖和适当的丙烯酸酯伙伴似乎遵循本文总结的格拉布斯规则。此外，还介绍了一种交叉甲基化产物的氢化方法。这些化合物和方法可用于水性涂料应用、粘合剂、润滑剂或任何需要在水性介质中分散的产品。
• CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING THEM
  申请人：EDGAR Kevin J.

  公开号：US20160215068A1

  公开（公告）日：2016-07-28

  Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose co-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.
• POLYSACCHARIDE DERIVATIVES AND CROSS-METATHESIS PROCESSES FOR PREPARING THEM
  申请人：Edgar Kevin J.

  公开号：US20160376379A1

  公开（公告）日：2016-12-29

  Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.