[Bu2Sn(N-[3-(trifluoromethyl)-phenyl]anthranilic acid(-1H))2] | 852328-38-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Bu2Sn(N-[3-(trifluoromethyl)-phenyl]anthranilic acid(-1H))2]
• CAS: 852328-38-2；852328-37-1
• 化学式: C₃₆H₃₆F₆N₂O₄Sn
• 分子量: 793.393
• InChiKey: ZQVKATMPMVXXQN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  氟灭酸 、 二正丁基氧化锡 以 苯 为溶剂， 以77%的产率得到[Bu2Sn(N-[3-(trifluoromethyl)-phenyl]anthranilic acid(-1H))2]
  参考文献：
  名称：

  Organotin flufenamates: Synthesis, characterization and antiproliferative activity of organotin flufenamates

  摘要：

  The organotin flufenamates [Me-2(flu)SnOSn(flu)Me-2](2) (1), [Bu-2(flu)SnOSn(flu)Bu-2](2) (2) and [Bu2Sn(flu)(2)] (3) have been prepared and structurally characterized by means of vibrational and NMR (H-1, C-13 and Sn-119) spectroscopy. The crystal structure of [Me-2(flu)SnOSn(flu)Me-2](2) (1) has been determined by X-ray crystallography. Three distannoxane rings are present to the dimeric tetraorganodistannoxane of planar ladder arrangement. The structure is centro-symmetric and features a central rhombus Sn2O2 unit with two additional tin atoms linked at the O atoms. Six-coordinated tin centers are present in the dimer distannoxane. This structure is self-assembled via pi -> pi and C-H -> pi stacking interactions. Flufenamic acid and flufenamates were evaluated for antiproliferative activity in vitro. Among the compounds tested [Bu-2(flu)SnOSn(flu)Bu-2](2) (2) and [Bu2Sn(flu)(2)] (3) exhibited high cytotoxic activity against the cancer cell line A549 (non-small cell lung carcinoma). (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2005.02.004