2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate | 182808-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate
• 英文别名: Olanzapine methanol；methanol;2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
• CAS: 182808-49-7
• 化学式: CH₄O*C₁₇H₂₀N₄S
• 分子量: 344.481
• InChiKey: RNAIHYAXTMRBIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.05
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲醇 、 奥氮平 以 丙酮 为溶剂， 反应 1.0h， 生成 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate
  参考文献：
  名称：

  [EN] PROCESSES FOR THE PREPARATION OF OLANZAPINE
  [FR] PROCEDES DE PREPARATION D'OLANZAPINE

  摘要：

  公开号：

  WO2006030300A3

文献信息

• Novel olanzapine forms and related methods of treatment
  申请人：Bourghol Hickey Magali

  公开号：US20060223794A1

  公开（公告）日：2006-10-05

  The invention provides novel soluble olanzapine forms. These forms include salts, co-crystals, and solvates of olanzapine. The invention also provides novel pharmaceutical compositions comprising these novel soluble forms and related methods of treatment. Compositions and methods of the invention of the invention are useful in the treatment of psychosis and functional bowel disorders.

  该发明提供了新型可溶性奥氮平形式。这些形式包括奥氮平的盐、共晶体和溶剂合物。该发明还提供了包含这些新型可溶性形式的新型药物组合物和相关的治疗方法。该发明的组合物和方法在治疗精神病和功能性肠道疾病方面是有用的。
• [EN] NOVEL OLANZAPINE FORMS AND RELATED METHODS OF TREATMENT<br/>[FR] NOUVELLES FORMES DE L'OLANZAPINE ET METHODES DE TRAITEMENT ASSOCIEES
  申请人：TRANSFORM PHARMACEUTICALS INC

  公开号：WO2004089313A2

  公开（公告）日：2004-10-21

  The invention provides novel soluble olanzapine forms. These forms include salts, co-crystals, and solvates of olanzapine. The invention also provides novel pharmaceutical compositions comprising these novel soluble forms and related methods of treatment. Compositions and methods of the invention of the invention are useful in the treatment of psychosis and functional bowel disorders.