2-(4-fluorophenyl)-thiazolidin-4-one | 299201-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-fluorophenyl)-thiazolidin-4-one
• 英文别名: 2-(4-Fluorophenyl)-1,3-thiazolidin-4-one
• CAS: 299201-11-9
• 化学式: C₉H₈FNOS
• mdl: MFCD00732066
• 分子量: 197.233
• InChiKey: NPCQHRHGZNWSQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-thiazolidin-4-one 、 丙烯腈 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以90%的产率得到3-(2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)propanenitrile
  参考文献：
  名称：

  Synthesis and antioxidant activity of some thiazolidin-4-one derivatives

  摘要：

  4-Fluorobenzaldehyde was used for the preparation of 2-(4-fluorophenyl) thiazolidin-4-one derivatives which were allowed to react with chloroacetonitrile and acrylonitrile to produce 3-(2-(4-fluorophenyl)-4-oxothiazolidine3-yl) acetonitrile and 3-(2-(4-fluorophenyl)-4-oxothiazoledine-3-yl) propanenitrile. Biological evaluation of some of the compounds showed that many had promising antioxidant activity.

  DOI：

  10.1007/s00706-008-0085-3
• 作为产物：
  描述：

  对氟苯甲醛 、 巯基乙酸 在 碳酸氢铵 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以86%的产率得到2-(4-fluorophenyl)-thiazolidin-4-one
  参考文献：
  名称：

  THIAZOLIDINONE COMPOUNDS AND USE THEREOF

  摘要：

  一种含有化合物（I）的药物组合物，用于治疗与阿片受体相关的疾病。还公开了一种使用这种化合物治疗阿片受体相关疾病的方法。进一步公开了两组式（I）的噻唑烷酮化合物：（i）每种化合物的对映体过量大于90%；（ii）每种化合物被氘取代。

  公开号：

  US20170253569A1

文献信息

• THIAZOLIDINONE COMPOUNDS AND USE THEREOF
  申请人：National Health Research Institutes

  公开号：US20170253569A1

  公开（公告）日：2017-09-07

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有化合物（I）的药物组合物，用于治疗与阿片受体相关的疾病。还公开了一种使用这种化合物治疗阿片受体相关疾病的方法。进一步公开了两组式（I）的噻唑烷酮化合物：（i）每种化合物的对映体过量大于90%；（ii）每种化合物被氘取代。
• Thiazolidinone compounds and use thereof
  申请人：National Health Research Institutes

  公开号：US10544113B2

  公开（公告）日：2020-01-28

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有用于治疗阿片受体相关疾病的式 (I) 化合物的药物组合物。还公开了一种使用此类化合物治疗阿片受体相关疾病的方法。进一步公开了两组式(I)的噻唑烷酮化合物：(i)对映体过量大于 90%的化合物和(ii)各自被氘取代的化合物。
• [EN] THIAZOLIDINONE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE THIAZOLIDINONE ET LEUR UTILISATION
  申请人：SHIH CHUAN

  公开号：WO2017155910A1

  公开（公告）日：2017-09-14

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.
• Synthesis and antioxidant activity of some thiazolidin-4-one derivatives
  作者：Ahmed O. H. El Nezhawy、Mostafa M. Ramla、Nagy M. Khalifa、Mohamed M. Abdulla

  DOI：10.1007/s00706-008-0085-3

  日期：2009.5

  4-Fluorobenzaldehyde was used for the preparation of 2-(4-fluorophenyl) thiazolidin-4-one derivatives which were allowed to react with chloroacetonitrile and acrylonitrile to produce 3-(2-(4-fluorophenyl)-4-oxothiazolidine3-yl) acetonitrile and 3-(2-(4-fluorophenyl)-4-oxothiazoledine-3-yl) propanenitrile. Biological evaluation of some of the compounds showed that many had promising antioxidant activity.