tetramethyl (5-nitro-1H-indol-1-yl)methylenediphosphonate | 1269412-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tetramethyl (5-nitro-1H-indol-1-yl)methylenediphosphonate
• 英文别名: 1-[Bis(dimethoxyphosphoryl)methyl]-5-nitroindole
• CAS: 1269412-97-6
• 化学式: C₁₃H₁₈N₂O₈P₂
• 分子量: 392.242
• InChiKey: AZVUSPNUTPXOFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  5-硝基吲哚 、 亚磷酸二甲酯 在 aluminum oxide 、 原甲酸三乙酯 作用下， 反应 0.2h， 以82%的产率得到tetramethyl (5-nitro-1H-indol-1-yl)methylenediphosphonate
  参考文献：
  名称：

  Green Synthesis of Aminobisphosphonates Under Microwave Irradiation

  摘要：

  A simple, efficient, and environmentally benign green chemical method has been developed for the synthesis of aminobisphosphonates by reacting aliphatic/aromatic 2 degrees-amines, dimethylphosphite, and triethylorthoformate by microwave irradiation under solvent-free conditions, in the presence of an alumina solid support. The advantages of this method are less reaction time, simple work-up, and excellent yields. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].

  DOI：

  10.1080/10426507.2010.482542

文献信息

• Green Synthesis of Aminobisphosphonates Under Microwave Irradiation
  作者：G. Chandra Sekhar Reddy、M. Veera Narayana Reddy、N. Bakthavatchala Reddy、C. Suresh Reddy

  DOI：10.1080/10426507.2010.482542

  日期：2010.12.30

  A simple, efficient, and environmentally benign green chemical method has been developed for the synthesis of aminobisphosphonates by reacting aliphatic/aromatic 2 degrees-amines, dimethylphosphite, and triethylorthoformate by microwave irradiation under solvent-free conditions, in the presence of an alumina solid support. The advantages of this method are less reaction time, simple work-up, and excellent yields. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].