1,3-bis(4-allyl-2-methoxyphenoxy)propane | 141492-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,3-bis(4-allyl-2-methoxyphenoxy)propane
• 英文别名: Trimethylenglykol-bis-(2-methoxy-4-allyl-phenyl)-aether；Trimethylendieugenol；1,3-Bis-(4-allyl-2-methoxy-phenoxy)-propan；2-Methoxy-1-[3-(2-methoxy-4-prop-2-enylphenoxy)propoxy]-4-prop-2-enylbenzene
• CAS: 141492-90-2
• 化学式: C₂₃H₂₈O₄
• 分子量: 368.473
• InChiKey: QWNASDFHBAUJNS-UHFFFAOYSA-N

物化性质

• 沸点：
  475.5±40.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-bis(4-allyl-2-methoxyphenoxy)propane 在 potassium permanganate 作用下， 生成 4-[3-(4-羧基-2-甲氧基苯氧基)丙氧基]-3-甲氧基苯甲酸
  参考文献：
  名称：

  Are the favorable outcomes of splenectomy predictable inpatients with idiopathic thrombocytopenic purpura (ITP)?

  摘要：

  Background Historically, splenectomy has been an accepted procedure in the management of immune thrombocytopenic purpura (ITP). However, it is also true that the response to splenectomy in patients with ITP seems to be unpredictable. Therefore, the purpose of this study was to identify clinical variables that might predict a favorable response to splenectomy in patients with ITP.Methods: Data were collected retrospectively for 40 adult patients with ITP who underwent laparoscopic (LS) and open (OS) splenectomy at Emory University Hospital between 1992 and 1999. Demographics and outcomes were recorded. Age, sex, disease duration, comorbidities (ASA > 2), previous response to steroids and/or other medications, and preoperative platelet count were analyzed by univariate (t-test, Fisher's exact test) and multivariate statistical methods.Results: Of the 20 patients in each group, improved platelet counts were noted in 18 patients in the LS group and 20 patients (100%) in the OS group. Follow-up (16 +/- 3 months,) was obtained in 19 LS patients (95%) and 16 OS patients (80%), with 84% and 87.5% sustained response rates, respectively. After univariate analysis, two variables (age and disease duration) were found to be significantly related to the outcome of splenectomy (p < 0.01). However, after multiple logistic regression analysis, only disease duration (relative risk = 1.083; Cl, 1.004-1.167) was an independent prognostic factor for a sustained response to splenectomy.Conclusion: These results suggest that the response to splenectomy (laparoscopic and open) in patients with ITP cannot be adequately predicted on the basis of presplenectomy clinical variables. However, disease duration and patient age should be taken into consideration when selecting patients for splenectomy.

  DOI：

  10.1007/s00464-001-8154-2
• 作为产物：
  描述：

  丁香酚 、 1,3-二碘丙烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 9.08h， 以49%的产率得到1,3-bis(4-allyl-2-methoxyphenoxy)propane
  参考文献：
  名称：

  丁香酚和百里香酚衍生物对牛乳腺炎的金黄色葡萄球菌的生物技术潜力

  摘要：

  牛乳腺炎是一种传染性疾病，会影响奶牛的乳腺，造成巨大的经济损失。金黄色葡萄球菌是这种高度传染性过程中涉及的主要微生物，仅使用抗生素进行治疗。当前，由于微生物抗性，仍需要寻找新的治疗方法和/或化合物。在这项工作中，我们评估了丁香酚和百里香酚衍生物对抗牛乳腺炎的金黄色葡萄球菌菌株的潜力。为此，从丁子香酚和百里酚（1-9）合成了9种衍生物，并针对15株金黄色葡萄球菌进行了测试。来自亚临床牛乳腺炎。最初，评估菌株的生物膜生产情况，并在最小抑制浓度（MIC）分析中选择具有强粘附性的菌株进行抗菌敏感性测定。本文中，化合物的毒性也通过使用软件的计算机分析来评估。结果表明，60％的菌株被认为是强粘附的，并且选择了三个菌株（金黄色葡萄球菌4271、4745和4746）进行MIC测试。在测试的九种丁香酚和百里酚衍生物中，有四种对评估菌株具有活性（MIC = 32 µg mL -1）在CLSI标准值之内。电脑分析表明，所有衍生物的cLopP

  DOI：

  10.1007/s00284-021-02344-9

文献信息

• Thermosettable resin compositions
  申请人：HERCULES INCORPORATED

  公开号：EP0304009A1

  公开（公告）日：1989-02-22

  Disclosed are a reaction mixture for preparing a poly­functional maleimide-based thermosettable resin composition comprising a bismaleimide or a polymaleimide and an ether derivative of an alkenylphenol; the polyfunctional maleimide-­based thermosettable resins comprising the reaction product of the reaction mixture; a process for the manufacture of the resins; and their use in a prepreg containing carbon, boron. glass or other fibers.

  公开了一种用于制备多官能团马来酰亚胺基热沉性树脂组合物的反应混合物，该组合物包括双马来酰亚胺或聚马来酰亚胺和烯基苯酚的醚衍生物；多官能团马来酰亚胺基热沉性树脂包括反应混合物的反应产物；树脂的制造工艺；以及它们在含有碳、硼、玻璃或其他纤维的预浸料中的用途。
• Bismaleimide compositions containing high glass transition temperature and soluble reactive oligomers and composites prepared therefrom
  申请人：HERCULES INCORPORATED

  公开号：EP0363524A1

  公开（公告）日：1990-04-18

  Described are (1) terminally unsaturated oligomers having terminal amine groups or terminal carboxylic acid derivative groups and glass transition temperatures (Tg) above about 170°, in which the unsaturated moieties have two double bonds in conjugated relationship, and which are soluble in uncured multifunctional maleimides, and (2) thermosetting resins com­prising mixtures of the terminally unsaturated oligomers and the multifunctional maleimides. The cured resins have a fracture toughness, KIC of at least 1.0 MPam1/2 and glass transition temperatures of at least 200°C.

  描述了(1)具有末端胺基或末端羧酸衍生物基团且玻璃化转变温度（Tg）高于约 170°的末端不饱和低聚物，其中不饱和分子具有两个共轭双键，且可溶于未固化的多功能马来酰亚胺，以及(2)由末端不饱和低聚物和多功能马来酰亚胺混合物组成的热固性树脂。固化树脂的断裂韧性、KIC 至少为 1.0 MPam1/2，玻璃化温度至少为 200°C。
• US4946908A
  申请人：——

  公开号：US4946908A

  公开（公告）日：1990-08-07
• US4962161A
  申请人：——

  公开号：US4962161A

  公开（公告）日：1990-10-09
• US5112924A
  申请人：——

  公开号：US5112924A

  公开（公告）日：1992-05-12