N-(4-pyridylmethyl)-L-valine hydrohloride | 1339132-59-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-pyridylmethyl)-L-valine hydrohloride
• 英文别名: N-(4-pyridylmethyl)-l-valine hydrochloride；(2S)-3-methyl-2-(pyridin-4-ylmethylamino)butanoic acid monohydrochloride；N-(4-pyridylmethyl)-L-valine monohydrochloride；N-(4-pyridylmethyl)-L-valine.HCl；(2S)-3-methyl-2-(pyridin-4-ylmethylamino)butanoic acid;hydrochloride
• CAS: 1339132-59-0
• 化学式: C₁₁H₁₆N₂O₂*ClH
• 分子量: 244.721
• InChiKey: ZHJDRQUPZYSZTC-PPHPATTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  62.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-pyridylmethyl)-L-valine hydrohloride 、 zinc(II) acetate dihydrate 以 水 为溶剂， 反应 0.17h， 以71%的产率得到[Zn(L-L₁Cl)(Cl)](H₂O)2
  参考文献：
  名称：

  WATER SOLUBLE METAL-ORGANIC FRAMEWORKS (MOFS)

  摘要：

  通过使用氨基酸衍生物和Zn(II)盐作为MOF构建单元，已经实现了一种高效、一步法的质子导电同手性金属有机框架的处理方法。通过合理设计配体结构，实现了对MOF溶解度和质子导电性的控制。这一发明将为工业应用中MOF薄膜的便捷制备铺平道路。

  公开号：

  US20140330020A1
• 作为产物：
  描述：

  4-吡啶甲醛 在 sodium tetrahydroborate 、 sodium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 N-(4-pyridylmethyl)-L-valine hydrohloride
  参考文献：
  名称：

  Helical Water Chain Mediated Proton Conductivity in Homochiral Metal–Organic Frameworks with Unprecedented Zeolitic unh-Topology

  摘要：

  Four new homochiral metal-organic framework (MOF) isomers, [Zn(l-L-Cl)(Cl)](H2O)(2) (1), [Zn(l-L-Br)(Br)]-(H2O)(2) (2), [Zn(d-L-Cl)(Cl)(H2O)(2) (3), and [Zn(d-L-Br)-(Br)] (H2O)(2) (4) [L = 3-methyl-2-(pyridin-4-ylmethylamino)-butanoic acid], have been synthesized by using a derivative of L-/D-valine and Zn(CH3COO)(2)center dot 2H(2)O. A three-periodic lattice with a parallel ID helical channel was formed along the crystallographic c-axis. Molecular rearrangement results in an unprecedented zeolitic unh-toparigy in 1-4. In each case, two lattice water molecules (one H-bonded. to halogen atoms) form a secondary helical continuous water chain inside the molecular helix. MOFs 1 and 2 shows different water adsorption properties and hence different water affinity. The arrangement of water molecules inside the channel Was monitored by variable temperature single crystal X-ray diffraction, which indicated that MOF 1 has a higher water holding capacity than MOF 2. In MOF 1, water escapes. at 80 degrees C, while in T the same happens at a much lower temperature (similar to 40 degrees C). All the MOFs reported here shows reversible crystallization by readily reabsorbing moisture. In MOFs 1 and 2, the frameworks are stable after solvent removal, which is confirmed by a single-crystal to single crystal transformation. MOFs 1 and 3 show high proton conductivity of 4.45 x 10(-5) and 4.42 x 10(-5) S cm(-1), respectively, while 2 and 4 shows zero proton conductivity. The above result is attributed to the fact that MOF 1 has a higher water holding capacity than MOF 2.

  DOI：

  10.1021/ja2078637

文献信息

• The biomimetic engineering of metal–organic frameworks with single-chiral-site precision for asymmetric hydrogenation
  作者：Jun Guo、Yulong Duan、Yangyang Liu、Huangxu Li、Yin Zhang、Chang Long、Zuming Wang、Yongchao Yang、Shenlong Zhao

  DOI：10.1039/d1ta08319h

  日期：——

  alkaloids on the single-chiral-site level. Among the presented engineered isoreticular valine (Val)-, serine (Ser)-, and threonine (Thr)-derived CMOFs, the Thr-MOF-supported Pt nanoparticles (NPs) exhibit impressive enantioselectivity in the asymmetric hydrogenation of ethyl pyruvate (EP) in addition to inherently robust catalytic recyclability without the need to add either fresh chiral ligands or

  基于多相金属纳米粒子（NPs）的不对称加氢由于其转化效率高、产物分离简单、催化剂再生方便等优点，在手性化学品的生产中引起了广泛关注。然而，其进一步的实际应用仍然受到昂贵的手性配体的浸出和相关的额外纯化成本的阻碍，这些额外的纯化成本是由金属纳米颗粒上手性配体的弱吸收引起的。相比之下，手性金属有机骨架（CMOFs）已被提议作为金属纳米颗粒载体和手性诱导剂，通过在单手性位点水平上对特权天然金鸡纳生物碱的配置进行仿生。在所提出的工程化等网状缬氨酸 (Val)-、丝氨酸 (Ser)- 和苏氨酸 (Thr) 衍生的 CMOF 中，Thr-MOF 支持的 Pt 纳米粒子 (NP) 在丙酮酸乙酯 (EP) 的不对称氢化中表现出令人印象深刻的对映选择性除了本质上强大的催化可回收性之外，无需添加新鲜的手性配体或 Pt NP。
• US9290518B2
  申请人：——

  公开号：US9290518B2

  公开（公告）日：2016-03-22