Kaempferol 8-C-sulfate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Kaempferol 8-C-sulfate
• 英文别名: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4-oxochromene-8-sulfonic acid
• 化学式: C₁₅H₁₀O₉S
• 分子量: 366.3
• InChiKey: LXSRUEIBKBIXFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  170
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• [EN] METHOD AND COMPOSITIONS FOR INHIBITING BIOSYNTHESIS OR BIOACTIVITY OF ENDOGENOUS STEROID SEX HORMONES IN HUMANS<br/>[FR] PROCEDE ET COMPOSITIONS D'INHIBITION DE LA BIOSYNTHESE OU DE LA BIOACTIVITE D'HORMONES SEXUELLES STEROIDIENNES ENDOGENES CHEZ DES SUJETS HUMAINS
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2001003687A2

  公开（公告）日：2001-01-18

  Disclosed is a method of inhibiting biosynthesis or bioactivity of endogenous steroid sex hormones in both men and women involving the administration of a combination of phytosterol(s) and phytoestrogen(s) to inhibit enzymatic activity in the steroidogenic biosynthetic pathway that converts steroid progestins and androgens to more potent steroidal hormones, like estradiol and dihydrotestosterone. Also disclosed is a pharmaceutical composition useful for inhibiting biosynthesis or bioactivity of endogenous steroid sex hormones in humans. The pharmaceutical composition is formulated in a delivery system to deliver a dose of 50 to 250 mg of a phytosterol(s), such as campesterol, sitosterol, fucosterol, stigmasterol, stigmastanol, or stigmastadienone, or a derivative or conjugate of any of these, and 20 to 150 mg of a phytoestrogen(s), such as a lignan, isoflavone, flavone, or coumestan compound(s).