(benzoxy) 3-[1,2-di-(10-undecenyl)-sn-glyceroxy] (N,N-diisopropylamino)phosphine | 188950-57-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (benzoxy) 3-[1,2-di-(10-undecenyl)-sn-glyceroxy] (N,N-diisopropylamino)phosphine
• 英文别名: N-[[(2R)-2,3-bis(undec-10-enoxy)propoxy]-phenylmethoxyphosphanyl]-N-propan-2-ylpropan-2-amine
• CAS: 188950-57-4
• 化学式: C₃₈H₆₈NO₄P
• 分子量: 633.936
• InChiKey: JJAQFKDMXZYBIF-FBOXOMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.2
• 重原子数：
  44
• 可旋转键数：
  32
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  40.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (benzoxy) 3-[1,2-di-(10-undecenyl)-sn-glyceroxy] (N,N-diisopropylamino)phosphine 在 四氮唑 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.08h， 生成 benzyl 3-[1,2-di-(10-undecenyl)-sn-glyceryl] 1-[2,6-di-O-benzoxymethyl-3-O-benzyl-4,5-O-(p-methoxybenzyl)-D-myo-inosityl] phosphate
  参考文献：
  名称：

  Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate

  摘要：

  The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.

  DOI：

  10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y
• 作为产物：
  描述：

  11-溴-1-十一烯 在 sodium hydride 、 N,N-二异丙基乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.42h， 生成 (benzoxy) 3-[1,2-di-(10-undecenyl)-sn-glyceroxy] (N,N-diisopropylamino)phosphine
  参考文献：
  名称：

  Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate

  摘要：

  The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.

  DOI：

  10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y

文献信息

• Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate
  作者：Jian Chen、Glenn D. Prestwich

  DOI：10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y

  日期：1997.3

  The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.