3,5,7,8-Tetrahydroxy-2-(4-methylphenyl)chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,5,7,8-Tetrahydroxy-2-(4-methylphenyl)chromen-4-one
• 英文别名: 3,5,7,8-tetrahydroxy-2-(4-methylphenyl)chromen-4-one
• 化学式: C₁₆H₁₂O₆
• 分子量: 300.26
• InChiKey: NTOABOYFEFSHCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• CDK5 Inhibitors and Therapeutic Uses Thereof
  申请人：The Hong Kong University of Science and Technology

  公开号：US20150119348A1

  公开（公告）日：2015-04-30

  Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.
• US9629863B2
  申请人：——

  公开号：US9629863B2

  公开（公告）日：2017-04-25