5-O-Methylmyricetin | 19077-84-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-O-Methylmyricetin
• 英文别名: 3,7-dihydroxy-5-methoxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one
• CAS: 19077-84-0
• 化学式: C₁₆H₁₂O₈
• 分子量: 332.26
• InChiKey: DDVGNSDGGWHPQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• [EN] POLYPHENOL-PEPTIDE CONJUGATES FOR NUCLEAR-TARGETED DELIVERY<br/>[FR] CONJUGUÉS POLYPHÉNOL-PEPTIDE POUR L'ADMINISTRATION CIBLANT LE NOYAU
  申请人：UNIV WIEN

  公开号：WO2020136240A1

  公开（公告）日：2020-07-02

  The present invention relates to a polyphenol-peptide conjugate composed of: (i) a peptide comprising the amino acid sequence Arg-Arg-X1-Leu, wherein X1 refers to one or two hydrophobic amino acids selected independently from lie, Leu, Val, Phe, Trp, and Met; (ii) at least one polyphenol which is covalently bound to the peptide; and (iii) optionally at least one cargo which, if present, is covalently bound to the peptide. The polyphenol-peptide conjugate can be encapsulated with silica. The invention thus also provides silica particles comprising the polyphenol-peptide conjugate encapsulated by a silica shell. The silica particles allow the efficient cellular uptake and targeted delivery of the polyphenol-peptide conjugate into the cell nucleus, and can therefore advantageously be used for nuclear-targeted gene or drug delivery.

  本发明涉及一种由以下组成的多酚-肽共轭物：（i）包括氨基酸序列Arg-Arg-X1-Leu的肽，其中X1是从lie、Leu、Val、Phe、Trp和Met中独立选择的一个或两个疏水性氨基酸；（ii）至少一种共价结合到肽上的多酚；以及（iii）可选地，至少一种共价结合到肽上的载荷。多酚-肽共轭物可以被硅化物封装。因此，本发明还提供了由硅壳封装的多酚-肽共轭物的硅颗粒。硅颗粒能够有效地被细胞摄取并定向传递到细胞核中，因此可以有利地用于核靶向基因或药物传递。
• HAIR DEFORMATION TREATMENT AGENT
  申请人：Kao Corporation

  公开号：EP3228303A1

  公开（公告）日：2017-10-11

  An agent for hair deforming treatment comprising the following components (A) to (C): (A) glyoxylic acid or a hydrate or salt thereof, (B) a compound represented by the following formula (1): wherein R1 represents H or a methyl group, X represents H, OH, or a methoxy group, Y represents H, O, OH, or a methoxy group, Z represents H, an alkyl group, etc., Rx represents H, O, a methoxy group, etc., Ry represents H, OH, an aromatic hydrocarbon group, etc., and the dashed line optionally represents a double bond, and (C) water, wherein the molar ratio of the content of the component (B) to the content of the component (A), (B)/(A), is 0.01 or more and 5 or less.

  一种用于头发变形处理的制剂，由以下成分(A)至(C)组成： (A) 乙醛酸或其水合物或盐、 (B) 下式(1)所代表的化合物： 其中 R1 代表 H 或甲基，X 代表 H、OH 或甲氧基，Y 代表 H、O、OH 或甲氧基，Z 代表 H、烷基等，Rx 代表 H、O、甲氧基等，Ry 代表 H、OH、芳香烃基等，虚线可选代表双键，以及 (C) 水、 其中，组分（B）的含量与组分（A）的含量的摩尔比，(B)/(A)，为 0.01 或以上，5 或以下。
• POLYPHENOL-PEPTIDE CONJUGATES FOR NUCLEAR-TARGETED DELIVERY
  申请人：Universität Wien

  公开号：EP3673920A1

  公开（公告）日：2020-07-01

  The present invention relates to a polyphenol-peptide conjugate composed of: (i) a peptide comprising the amino acid sequence Arg-Arg-X1-Leu, wherein X1 refers to one or two hydrophobic amino acids selected independently from lie, Leu, Val, Phe, Trp, and Met; (ii) at least one polyphenol which is covalently bound to the peptide; and (iii) optionally at least one cargo which, if present, is covalently bound to the peptide. The polyphenol-peptide conjugate can be encapsulated with silica. The invention thus also provides silica particles comprising the polyphenol-peptide conjugate encapsulated by a silica shell. The silica particles allow the efficient cellular uptake and targeted delivery of the polyphenol-peptide conjugate into the cell nucleus, and can therefore advantageously be used for nuclear-targeted gene or drug delivery.

  本发明涉及一种多酚-多肽共轭物，其组成包括：(i) 包含 Arg-Arg-X1-Leu 氨基酸序列的多肽，其中 X1 指从 lie、Leu、Val、Phe、Trp 和 Met 中独立选出的一个或两个疏水氨基酸；(ii) 至少一种与多肽共价结合的多酚；(iii) 可选的至少一种与多肽共价结合的货物（如果存在）。多酚-肽共轭物可以用二氧化硅封装。因此，本发明还提供了由二氧化硅外壳封装的多酚肽共轭物组成的二氧化硅颗粒。这种二氧化硅颗粒可使多酚多肽共轭物有效地被细胞吸收并定向递送到细胞核中，因此可用于核靶向基因或药物递送。
• Hair cosmetic composition
  申请人：KAO CORPORATION

  公开号：US10959925B2

  公开（公告）日：2021-03-30

  The hair cosmetic composition of the present invention, which is a one-agent type or a multi-agent type hair cosmetic composition, contains, the following components (A) to (D), the component (C) content, relative to the total composition of the hair cosmetic composition, being 0.1 mass % or higher and lower than 20 mass %: (A): a compound selected from the group consisting of glyoxylic acid, a glyoxylic acid hydrate, a glyoxylate salt, and a glyoxylamide; (B): a phenolic compound having an electron-donating group on at least one m-position and having a hydrogen atom on at least one of the o-positions and the p-position, wherein the electron-donating group on the m-position may form, together with an adjacent carbon atom, a benzene ring optionally substituted with hydroxyl group(s); (C): an organic solvent having a boiling point of 100° C. or higher; and (D): water.

  本发明的头发化妆品组合物是一种单药剂型或多药剂型头发化妆品组合物，含有以下成分（A）至（D），其中成分（C）的含量相对于头发化妆品组合物的总成分而言，大于或等于 0.1 质量%，小于 20 质量%： (A): 选自乙醛酸、乙醛酸水合物、乙醛酸盐和乙醛酰胺组成的化合物； (B) 一种酚类化合物，其至少一个 m 位上有一个电子供体，至少一个 o 位和 p 位上有一个氢原子，其中 m 位上的电子供体可与相邻的碳原子一起形成一个任选被羟基取代的苯环； (C) 沸点为 100 摄氏度或更高的有机溶剂；以及 (D) 水。
• AGENT FOR HAIR DEFORMING TREATMENT
  申请人：Kao Corporation

  公开号：EP3228303B1

  公开（公告）日：2020-03-18