4-phenyl-2-hydrazinooxazole | 95458-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-phenyl-2-hydrazinooxazole
• 英文别名: 2-hydrazino-4-phenyloxazole；(4-Phenyl-1,3-oxazol-2-yl)hydrazine
• CAS: 95458-69-8
• 化学式: C₉H₉N₃O
• 分子量: 175.19
• InChiKey: KMIYDIMMAZXFMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-phenyl-2-hydrazinooxazole 生成 3-[1-(4-Phenyl-2-oxazolyl)-hydrazino]propanenitrile hydrochloride
  参考文献：
  名称：

  HAVIV, F.;KERDESKY, F. A. J.

  摘要：

  DOI：
• 作为产物：
  描述：

  S-(4-叔-丁基苯甲基)[2-(1-甲基丁基)吡啶-3-基]硫代氨基甲酸酯 、 2-溴苯乙酮 在 盐酸 、 ammonium chloride 作用下， 生成 4-phenyl-2-hydrazinooxazole
  参考文献：
  名称：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation

  摘要：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.

  DOI：

  10.1021/jm00117a010

文献信息

• [1-(2-Oxazolyl) or -(2-thiazolyl) hydrazino]alkyl nitriles
  申请人：Abbott Laboratories

  公开号：US04489084A1

  公开（公告）日：1984-12-18

  Described are oxazolyl (or thiazolyl) hydrazinoalkyl nitrile compounds of the formula ##STR1## wherein R is hydrogen or loweralkyl, R.sub.1 and R.sub.2 independently of one another denote hydrogen, loweralkyl, or phenyl or naphthyl substituted with halo, loweralkyl or loweralkoxy, X is oxygen or sulfur, n and m are each an integer from 0 to 3 inclusive, or pharmaceutically acceptable salts thereof. The compounds are useful as anti-inflammatory agents.

  本文描述了一种式子为##STR1##的噁唑基（或噻唑基）肼基烷基腈化合物，其中R是氢或低碳基，R.sub.1和R.sub.2分别独立地表示氢、低碳基或带有卤素、低碳基或低碳氧基取代的苯基或萘基，X是氧或硫，n和m均为0到3的整数，或其药学上可接受的盐。这些化合物可用作抗炎药物。
• HAVIV, F.;KERDESKY, F. A. J.
  作者：HAVIV, F.、KERDESKY, F. A. J.

  DOI：——

  日期：——
• HAVIV, FORTUNA;RATAJCZYK, JAMES D.;DENET, ROBERT W.;KERDESKY, FRANCIS A.;+, J. MED. CHEM., 31,(1988) N 9, C. 1719-1728
  作者：HAVIV, FORTUNA、RATAJCZYK, JAMES D.、DENET, ROBERT W.、KERDESKY, FRANCIS A.、+

  DOI：——

  日期：——
• US4489084A
  申请人：——

  公开号：US4489084A

  公开（公告）日：1984-12-18
• 3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation
  作者：Fortuna Haviv、James D. Ratajczyk、Robert W. DeNet、Francis A. Kerdesky、Roland L. Walters、Steven P. Schmidt、James H. Holms、Patrick R. Young、George W. Carter

  DOI：10.1021/jm00117a010

  日期：1988.9

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.