4-Butyl-5-propyl-thiazol | 57246-59-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Butyl-5-propyl-thiazol
• 英文别名: 4-butyl-5-propyl-thiazole；4-Butyl-5-propylthiazole；4-butyl-5-propyl-1,3-thiazole
• CAS: 57246-59-0
• 化学式: C₁₀H₁₇NS
• mdl: MFCD18451970
• 分子量: 183.318
• InChiKey: AHPGPUJQEGRVBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• WATER CHANNEL OPENER COMPOSITIONS AND MEDICINAL COMPOSITIONS FOR OPHTHALMIC USE
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1206942A1

  公开（公告）日：2002-05-22

  The present invention is to provide a novel water channel opener having the activity to open an AQP water channel and a pharmaceutical composition for ophthalmic use comprising the opener as an active ingredient, particularly a lacrimation stimulant,. The present invention is directed to a water channel opener composition which comprises a ligand of lipocalin, particularly a compound having odorant binding protein-binding activity, and a pharmaceutical composition for ophthalmic use which comprises the opener as an active ingredient, particularly a lacrimation stimulant composition.

  本发明旨在提供一种具有打开AQP水通道活性的新型水通道开启剂，以及一种包含该开启剂作为活性成分的眼科用药物组合物，特别是一种泪液刺激剂。 本发明涉及一种水通道开启剂组合物，该组合物包含脂褐素的配体，特别是具有气味结合蛋白结合活性的化合物，以及一种眼科用药物组合物，该组合物包含该开启剂作为活性成分，特别是一种泪液刺激剂组合物。
• Water channel opener compositions and medicinal compositions for ophthalmic use
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：US20040235742A1

  公开（公告）日：2004-11-25

  The present invention is to provide a novel water channel opener having the activity to open an AQP water channel and a pharmaceutical composition for ophthalmic use comprising the opener as an active ingredient, particularly a lacrimation stimulant. The present invention is directed to a water channel opener composition which comprises a ligand of lipocalin, particularly a compound having odorant binding protein-binding activity, and a pharmaceutical composition for ophthalmic use which comprises the opener as an active ingredient, particularly a lacrimation stimulant composition.