5-Hydroxy-7-(hydroxymethyl)-2-phenyl-2,3-dihydrochromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-Hydroxy-7-(hydroxymethyl)-2-phenyl-2,3-dihydrochromen-4-one
• 英文别名: 5-hydroxy-7-(hydroxymethyl)-2-phenyl-2,3-dihydrochromen-4-one
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.28
• InChiKey: AZTAQMQWFPLFOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• KAVA DERIVED THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：XING Chengguo

  公开号：US20160279184A1

  公开（公告）日：2016-09-29

  Certain embodiments of the invention provide a composition comprising at least two compounds selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the composition is substantially free of flavokawain B. Certain embodiments of the invention also provide a method for treating or preventing cancer in a mammal (e.g., a human) in need of such treatment comprising, administering to the mammal a carrier and a compound selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the compound is substantially free of other kava extract components.