3,3'-((5-nitrofuran-2-yl)methylene)bis(1H-indole) | 893250-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3,3'-((5-nitrofuran-2-yl)methylene)bis(1H-indole)
• 英文别名: 3-[1H-indol-3-yl-(5-nitrofuran-2-yl)methyl]-1H-indole
• CAS: 893250-69-6
• 化学式: C₂₁H₁₅N₃O₃
• 分子量: 357.368
• InChiKey: YSNWZYCWQHYUNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚 、 5-硝基糠醛 在 C₆₂H₅₈N₈O₂₀Y₂Zn₂ 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 生成 3,3'-((5-nitrofuran-2-yl)methylene)bis(1H-indole)
  参考文献：
  名称：

  四核3d / 4f配位簇是Friedel Crafts烷基化反应的高效催化剂

  摘要：

  首次描述了一系列定制设计的高收率等骨架四核3d / 4f配位簇，这些化合物在弗里德尔工艺烷基化反应中作为低催化负载的催化剂表现出了高效率。

  DOI：

  10.1039/c6cc03608b

文献信息

• Discovery of 3,3′-diindolylmethanes as potent antileishmanial agents
  作者：Sandip B. Bharate、Jaideep B. Bharate、Shabana I. Khan、Babu L. Tekwani、Melissa R. Jacob、Ramesh Mudududdla、Rammohan R. Yadav、Baljinder Singh、P.R. Sharma、Sudip Maity、Baldev Singh、Ikhlas A. Khan、Ram A. Vishwakarma

  DOI：10.1016/j.ejmech.2013.02.024

  日期：2013.5

  An efficient protocol for synthesis of 3,3'-diindolylmethanes using recyclable Fe-pillared interlayered clay (Fe-PILC) catalyst under aqueous medium has been developed. All synthesized 3,3'-diindolylmethanes showed promising antileishmanial activity against Leishmania donovani promastigotes as well as axenic amastigotes. Structure-activity relationship analysis revealed that nitroaryl substituted diindolylmethanes showed potent antileishmanial activity. The 4-nitrophenyl linked 3,3'-diindolylmethane 8g was found to be the most potent antileishmanial analog showing IC50 values of 7.88 and 8.37 mu M against both L donovani promastigotes and amastigotes, respectively. Further, a pharmacophore based QSAR model was established to understand the crucial molecular features of 3,3'-diindolylmethanes essential for potent antileishmanial activity. These compounds also exhibited promising antifungal activity against Cryptococcus neoformans, wherein fluorophenyl substituted 3,3'-diindolylmethanes were found to be most potent antifungal agents. Developed synthetic protocol will be useful for economical and eco-friendly synthesis of potent antileishmanial and antifungal 3,3'-diindolylmethane class of compounds. (C) 2013 Elsevier Masson SAS. All rights reserved.
• Tetranuclear Zn/4f coordination clusters as highly efficient catalysts for Friedel–Crafts alkylation
  作者：Kieran Griffiths、Prashant Kumar、Geoffrey R. Akien、Nicholas F. Chilton、Alaa Abdul-Sada、Graham J. Tizzard、Simon J. Coles、George E. Kostakis

  DOI：10.1039/c6cc03608b

  日期：——

  A series of custom-designed high yield isoskeletal tetranuclear 3d/4f coordination clusters showing high efficiency as catalysts with low catalytic loadings in Friedel Crafts alkylation are described for the first time....

  首次描述了一系列定制设计的高收率等骨架四核3d / 4f配位簇，这些化合物在弗里德尔工艺烷基化反应中作为低催化负载的催化剂表现出了高效率。