3-(3,4-Dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile | 875283-46-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(3,4-Dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile
• 英文别名: 2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
• CAS: 875283-46-8
• 化学式: C₁₆H₁₁NO₅
• 分子量: 297.26
• InChiKey: CANOJKGQDCJDOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHOD OF INHIBITING THE GROWTH OF HELICOBACTER PYLORI
  申请人：WANG WEN-CHING

  公开号：US20100305152A1

  公开（公告）日：2010-12-02

  The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds, which is an attractive target for the rational drug and herbicide design because it is essential in algae, higher plants, bacteria, and fungi, but absent from mammals. Thus, the present invention provides a method of inhibiting the growth of bacteria or fungi, especially Helicobacter pylori, through inhibiting enzymes in the shikimate pathway.
• Phosphoinositide (4,5) Bisphosphate as a Diagnostic Tool and Target for Cancer Treatment
  申请人：Janetopoulos Christopher

  公开号：US20160266129A1

  公开（公告）日：2016-09-15

  The present invention relates to PI(4,5)P2 and more particularly to use of enzymes that metabolize and regulate the PI(4,5)P2 levels as a as a target for cancer treatment. Furthermore, measuring the level of PI(4,5)P2 or the degree of turnover of PI(4,5)P2 in cancer cells is an important diagnostic tool.
• US8175860B2
  申请人：——

  公开号：US8175860B2

  公开（公告）日：2012-05-08