6,7-dimethoxy-4-spirocyclopentane-3,4-dihydroisoquinoline-1-carboxylic acid N-methylamide | 331964-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 6,7-dimethoxy-4-spirocyclopentane-3,4-dihydroisoquinoline-1-carboxylic acid N-methylamide
• 英文别名: 6,7-dimethoxy-N-methylspiro[3H-isoquinoline-4,1'-cyclopentane]-1-carboxamide
• CAS: 331964-75-1
• 化学式: C₁₇H₂₂N₂O₃
• 分子量: 302.373
• InChiKey: PNOUQWFXFGTKST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-4-spirocyclopentane-3,4-dihydroisoquinoline-1-carboxylic acid N-methylamide 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以66.2%的产率得到N-methyl-6',7'-dimethoxy-2',3'-dihydro-1'H-spiro[cyclopentan-1,4'-isoquinoline]-1'-carboxamide
  参考文献：
  名称：

  Synthesis of novel 1,2-functionally-substituted 6,7-dimethoxy-4-spirocyclo-pentanetetrahydroisoquinolines

  摘要：

  1-[( 3,4-Dimethoxyphenyl)cyclopentyl] methylamine has been used in the synthesis of 6,7-dimethoxy4- spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide which is employed in the preparation of novel derivatives with substituents in positions 1,2,6, and 7.

  DOI：

  10.1007/s10593-009-0385-5
• 作为产物：
  描述：

  oxalic acid N-methyl-N'-[1-(3,4-dimethoxyphenyl)cyclopentylmethyl]amide 在 三氯氧磷 作用下， 以 乙腈 为溶剂， 生成 6,7-dimethoxy-4-spirocyclopentane-3,4-dihydroisoquinoline-1-carboxylic acid N-methylamide
  参考文献：
  名称：

  Synthesis of novel 1,2-functionally-substituted 6,7-dimethoxy-4-spirocyclo-pentanetetrahydroisoquinolines

  摘要：

  1-[( 3,4-Dimethoxyphenyl)cyclopentyl] methylamine has been used in the synthesis of 6,7-dimethoxy4- spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide which is employed in the preparation of novel derivatives with substituents in positions 1,2,6, and 7.

  DOI：

  10.1007/s10593-009-0385-5

文献信息

• Synthesis of novel 1,2-functionally-substituted 6,7-dimethoxy-4-spirocyclo-pentanetetrahydroisoquinolines
  作者：A. A. Aghekyan、E. A. Arakelyan、G. A. Panosyan、A. G. Khachatryan、E. A. Markaryan

  DOI：10.1007/s10593-009-0385-5

  日期：2009.9

  1-[( 3,4-Dimethoxyphenyl)cyclopentyl] methylamine has been used in the synthesis of 6,7-dimethoxy4- spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide which is employed in the preparation of novel derivatives with substituents in positions 1,2,6, and 7.