4a,6a,7-trimethyl-2,3,4,4a,4b,5,6,6a,10,10a,10b,11-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,2]oxazol-2-ol | 101037-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4a,6a,7-trimethyl-2,3,4,4a,4b,5,6,6a,10,10a,10b,11-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,2]oxazol-2-ol
• 英文别名: 7,9,13-trimethyl-5-oxa-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-4(8),6,18-trien-16-ol
• CAS: 101037-64-3
• 化学式: C₂₁H₂₉NO₂
• 分子量: 327.467
• InChiKey: CWEKHXSSQMBRHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING NOROVIRUS INFECTION
  申请人：Children's Hospital Medical Center

  公开号：US20160193229A1

  公开（公告）日：2016-07-07

  A composition for use in inhibiting the binding of a Norovirus to the histo-blood group antigen on the surface of epithelia is disclosed. The composition may contain a therapeutically effective amount of a binding-inhibiting compound and a carrier and/or excipient. The compounds may competitively bind a Norovirus that has the capability of binding with the histo-blood group antigens of secretor blood type, including A, B, AB, and O blood types. The compositions may be administered to a human prior to or after infection by a Norovirus, to prevent, ameliorate, or reduce the effects of an infection.
• US9321803B2
  申请人：——

  公开号：US9321803B2

  公开（公告）日：2016-04-26
• US9561239B2
  申请人：——

  公开号：US9561239B2

  公开（公告）日：2017-02-07