2-butyl-3-methyl-succinic acid | 76904-17-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-butyl-3-methyl-succinic acid
• 英文别名: 2-Butyl-3-methyl-bernsteinsaeure；2-Butyl-3-methylbutanedioic acid
• CAS: 76904-17-1
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: DGBKTJIQJQNAIN-UHFFFAOYSA-N

物化性质

• 熔点：
  140-141 °C
• 沸点：
  290.1±13.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-butyl-3-methyl-succinic acid 在 吡啶 、 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 2-butyl-3-methyl-buta-1,3-diene
  参考文献：
  名称：

  The Synthesis and Polymerization of Some 2-Methyl-3-alkyl-1,3-butadienes¹

  摘要：

  DOI：

  10.1021/ja01126a046
• 作为产物：
  描述：

  2-溴丙酸 、 己酸 生成 2-butyl-3-methyl-succinic acid
  参考文献：
  名称：

  The Reaction of Lithium α-Lithiocarboxylates (Dianions of Carboxylic Acids) or α-Lithiocarboxylic Esters (Ester Enolates) with α-Halocarboxylic Esters or Lithium α-Halocarboxylates

  摘要：

  DOI：

  10.1055/s-1980-29181

文献信息

• [EN] DEUTERATED TANDOSPIRONE DERIVATIVES AS 5-HT1A RECEPTOR AGONISTS<br/>[FR] DÉRIVÉS DEUTÉRÉS DE TANDOSPIRONE CONVENANT COMME AGONISTES DU RÉCEPTEUR 5-HT1A
  申请人：CONRIG PHARMA APS

  公开号：WO2012016569A1

  公开（公告）日：2012-02-09

  The present invention relates to new deuterated derivatives of serotonin 5-HT1A receptor agonists of formula 1 and in particular to compositions and methods for therapeutic use.

  本发明涉及公式1的新的氘代衍生物，特别是用于治疗的组合物和方法。
• [EN] PROTEIN PHOSPHATASE INHIBITORS THAT CROSS THE BLOOD BRAIN BARRIER<br/>[FR] INHIBITEURS DE PROTÉINES PHOSPHATASES QUI TRAVERSENT LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
  申请人：LIXTE BIOTECHNOLOGY INC

  公开号：WO2015073802A1

  公开（公告）日：2015-05-21

  The present invention provides a method for in vivo delivery of endothal to a target cell in a subject, the method comprising administering to the subject a compound having the structure: Formula (I).

  本发明提供了一种用于在体内将内托尔传递到受体细胞的方法，该方法包括向受体施用具有以下结构的化合物：Formula (I)。
• Crosslinked, porous polymers for controlled delivery of agricultural ingredients
  申请人：CIBA-GEIGY AG

  公开号：EP0190996A2

  公开（公告）日：1986-08-13

  A controlled-release, delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99 % by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45 % weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1 % by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of an active agricultural ingredient is useful for the controlled and prolonged release of said ingredient.

  一种控释给药组合物，它包括(A)一种交联共聚物，该共聚物能在乙醇中溶胀，得到含乙醇至少 40%（重量）的溶胀共聚物，并能在水中溶胀，得到含水不超过 20%（重量）的溶胀共聚物，其中溶胀比（乙醇百分比：水百分比）为 2:1 至 22:1：(A)50-99%（重量百分比）的水不溶性单烯烃单体或(a)0-45%（重量百分比）的水溶性单烯烃单体与(b)50-1%（重量百分比）但不超过 20 摩尔%的二乙烯基或聚乙烯交联剂的共聚产物；以及(B)有效量的农业活性成分，有助于控制和延长所述成分的释放。
• CELLULOSE ESTER FILM, PROCESS FOR PRODUCING CELLULOSE ESTER FILM, OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY UNIT
  申请人：Konica Minolta Opto, Inc.

  公开号：EP1967541A1

  公开（公告）日：2008-09-10

  A cellulose ester film that excels in uniformity of retardation as an optical property, especially uniformity of retardation in the direction of film width, and further contrast; a process for producing such a cellulose ester film; and making use of the film, an optical film, polarizing plate and liquid crystal display unit. There is provided a process characterized by subjecting, to melting film formation, a solid cellulose ester having been suspension washed with a poor organic solvent to cellulose ester in the presence of an antioxidant so that the content of free acids in the cellulose ester is 50 ppm or less.

  一种纤维素酯薄膜，它在作为光学特性的延迟均匀性，特别是在薄膜宽度方向上的延迟均匀性以及进一步的对比度方面表现出色；一种生产这种纤维素酯薄膜的工艺；以及利用该薄膜、光学薄膜、偏光板和液晶显示装置。本发明提供了一种工艺，其特点是将用贫有机溶剂悬浮洗涤过的固体纤维素酯在抗氧化剂存在下熔融成膜，使纤维素酯中的游离酸含量为 50ppm 或更少。
• Polypropylene based composition
  申请人：Repsol, S.A.

  公开号：EP2883925A1

  公开（公告）日：2015-06-17

  Polypropylene based compositions, multi-layer barrier structures comprising them and their preparation process. The composition comprises a polypropylene grafted based resin as main component, a polypropylene homo- or copolymer, an ethylene copolymer based component and a nucleator which acts as promoter of the adhesion of the composition.

  聚丙烯基组合物、由其构成的多层阻隔结构及其制备工艺。这种组合物包括一种聚丙烯接枝树脂（作为主要成分）、一种聚丙烯均聚物或共聚物、一种乙烯共聚物成分和一种成核剂（可促进组合物的粘合）。