2-[(4-Chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]acetic acid | 593260-47-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-Chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]acetic acid
• CAS: 593260-47-0
• 化学式: C₁₆H₁₆ClNO₄S
• 分子量: 353.826
• InChiKey: YAMAMKNVUJSISM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[(4-Chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]acetic acid 在 palladium on activated charcoal 三苯基膦树脂 、 四溴化碳 、 氢气 、 三乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 、 异丙醇 为溶剂， 生成 2-[(4-chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]-N-hydroxyacetamide
  参考文献：
  名称：

  Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

  摘要：

  Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00311-x
• 作为产物：
  描述：

  N-tosylglycine t-butyl ester 在 polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-[(4-Chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]acetic acid
  参考文献：
  名称：

  Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

  摘要：

  Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00311-x

文献信息

• Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents
  作者：Marina Caldarelli、Jörg Habermann、Steven V. Ley

  DOI：10.1016/s0960-894x(99)00311-x

  日期：1999.7

  Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step. (C) 1999 Elsevier Science Ltd. All rights reserved.