BE-32030B

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: BE-32030B
• 英文别名: [4-[(1-hydroxy-2-oxoazepan-3-yl)amino]-4-oxobutan-2-yl] 2-[[2-(2-hydroxyphenyl)-4-methyl-5H-1,3-oxazole-4-carbonyl]amino]-6-[hydroxy(tetradecanoyl)amino]hexanoate
• 化学式: C₄₁H₆₅N₅O₁₀
• 分子量: 787.995
• InChiKey: FLNBHUFQQNURAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  56
• 可旋转键数：
  26
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  207
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  甲醇 、 BE-32030B 在 sodium hydroxide 作用下， 反应 2.0h， 以19.7 mg的产率得到BE-32030B-1
  参考文献：
  名称：

  BE-32030 A, B, C, D and E, New Antitumor Substances Produced by Nocardia sp. A32030.

  摘要：

  New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.

  DOI：

  10.7164/antibiotics.50.815

文献信息

• BE-32030 A, B, C, D and E, New Antitumor Substances Produced by Nocardia sp. A32030.
  作者：MASAO TSUKAMOTO、KUMIKO MUROOKA、SHIGERU NAKAJIMA、SHINNOSUKE ABE、HAJIME SUZUKI、KAORI HIRANO、HISAO KONDO、KATSUHISA KOJIRI、HIROYUKI SUDA

  DOI：10.7164/antibiotics.50.815

  日期：——

  New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.