methyl 2-hydroxy-2-methylbutanoate | 32793-34-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 2-hydroxy-2-methylbutanoate
• 英文别名: methyl 2-hydroxy-2-methylbutyrate；methyl 2-methyl-2-hydroxybutanate；2-hydroxy-2-methyl-butyric acid methyl ester；2-Hydroxy-2-methyl-buttersaeure-methylester；Methylaethylglykolsaeuremethylester；α-Hydroxy-α-methylbuttersaeure-Me-ester
• CAS: 32793-34-3
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: FMXYCZVOMYLMKM-UHFFFAOYSA-N

物化性质

• LogP：
  0.162 (est)
• 保留指数：
  923

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-hydroxy-2-methylbutanoate 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 methyl (2S)-2-([1-[(2-chlorophenyl)methyl]-5-(3-methoxyphenyl)-1H-pyrazol-3-yl]methoxy)-2-methylbutanoate
  参考文献：
  名称：

  HETEROCYCLIC INHIBITORS OF MCT4

  摘要：

  本文披露了一些化合物和组合物，适用于治疗由MCT4介导的疾病，如增殖性和炎症性疾病，其结构如下所示： 还提供了在人类或动物主体中抑制MCT4活性的方法。

  公开号：

  US20180162822A1
• 作为产物：
  描述：

  2-羟基-2-甲基丁酸 在 草酰氯 作用下， 以 苯 为溶剂， 生成 methyl 2-hydroxy-2-methylbutanoate
  参考文献：
  名称：

  371.一些α-酰氧基酰氯的新反应

  摘要：

  DOI：

  10.1039/jr9640001918

文献信息

• General and Efficient α-Oxygenation of Carbonyl Compounds by TEMPO Induced by Single-Electron-Transfer Oxidation of Their Enolates
  作者：Emanuela Dinca、Philip Hartmann、Jakub Smrček、Ina Dix、Peter G. Jones、Ullrich Jahn

  DOI：10.1002/ejoc.201200736

  日期：2012.8

  for the synthesis of protected α-oxygenated carbonyl compounds is reported. It is based on the single-electron-transfer oxidation of easily generated enolates to the corresponding α-carbonyl radicals. Coupling with the stable free radical TEMPO provides α-(piperidinyloxy) ketones, esters, amides, acids or nitriles in moderate-to-excellent yields. Enolate aggregates influence the outcome of the oxygenation

  报道了一种普遍适用的合成受保护的 α-氧化羰基化合物的方法。它基于将容易生成的烯醇化物单电子转移氧化为相应的 α-羰基自由基。与稳定的自由基 TEMPO 结合以中等至优异的产率提供 α-(哌啶基氧基) 酮、酯、酰胺、酸或腈。烯醇化物聚集体显着影响氧化反应的结果。对竞争反应进行了分析，并提出了将其最小化的条件。产物的化学选择性还原导致 N-O 键裂解为 α-羟基羰基化合物或羰基官能团还原为单保护的 1,2-二醇或 O-保护的氨基醇。
• BISPHENOL HAVING FLUORENE SKELETON, METHOD FOR PRODUCING SAME, POLYARYLATE RESIN, (METH)ACRYLATE COMPOUND AND EPOXY RESIN WHICH ARE DERIVED FROM THE BISPHENOL
  申请人：TAOKA CHEMICAL CO., LTD.

  公开号：US20190055180A1

  公开（公告）日：2019-02-21

  Provided are a bisphenol represented by the general formula (1), a method for producing the bisphenol, and a polyarylate resin, a (meth)acrylate compound and an epoxy resin which are derived from the bisphenol. In the formula (1), R 1 to R 4 are the same or different, and each represent an alkyl group, an aryl group or a halogen atom, n 1 and n 2 are the same or different, and each represent an integer of 1 to 4, and k 1 to k 4 are the same or different, and each represent 0 or an integer of 1 to 4. When at least one of k 1 to k 4 is 2 or more, corresponding R 1 to R 4 may be the same or different.

  提供的是由通式（1）表示的双酚，一种生产双酚的方法，以及源自双酚的聚苯醚树脂、（甲基）丙烯酸酯化合物和环氧树脂。在式（1）中，R1至R4相同或不同，每个代表一个烷基、芳基或卤素原子，n1和n2相同或不同，每个代表1到4的整数，k1至k4相同或不同，每个代表0或1到4的整数。当k1至k4中至少有一个为2或更大时，相应的R1至R4可以相同或不同。
• Photosensitive resin compositon, transfer material, image forming method, color filter and producing method thereof and photomask and producing method thereof
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20030129504A1

  公开（公告）日：2003-07-10

  The invention provides a colored photosensitive resin composition for forming a colored image on a transparent substrate, the colored photosensitive resin composition comprising: an alkali-soluble binder, one of a monomer and an oligomer having at least two ethylenic unsaturated double bonds, one of a photopolymerization initiator and a photopolymerization initiating system, and a pigment, said alkali-soluble binder comprising a copolymer including a structural unit having a carboxyl group, a structural unit represented by the following general formula (1), and a structural unit comprising a (meth)acrylate having at least one of an aromatic ring and an alicyclic ring: General formula (1) 1 wherein R 1 represents one of a hydrogen atom and a methyl group; and each of R 2 to R 6 independently represents one of a hydrogen atom, a substituted and unsubstituted alkyl group, a substituted and unsubstituted aryl group, a halogen atom and a cyano group.

  本发明提供了一种用于在透明基板上形成彩色图像的彩色光敏树脂组合物，该彩色光敏树脂组合物包括：碱溶性粘合剂、具有至少两个乙烯基不饱和双键的单体或低聚物之一、光聚合引发剂或光聚合引发体系之一，以及颜料，其中所述碱溶性粘合剂包括共聚物，包括具有羧基的结构单元，以下一般式（1）所表示的结构单元，以及包含至少一个芳香环和脂环的（甲基）丙烯酸酯的结构单元：一般式（1）其中，R1表示氢原子和甲基基团中的一种；R2到R6中的每一个独立地表示氢原子、取代和未取代的烷基、取代和未取代的芳基、卤素原子和氰基中的一种。
• Substituted Imidazo Ring Systems and Methods
  申请人：Dellaria F. Joseph

  公开号：US20070259881A1

  公开（公告）日：2007-11-08

  Imidazo ring systems, which include, for example, imidazopyridine, imidazoquinoline, 6,7,8,9-tetrahydroimidazoquinoline, imidazonaphthyridine, and 6,7,8,9-tetrahydroimidazonaphthyridine compounds substituted at the 1-position and/or the 2-position, pharmaceutical compositions containing these compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本文介绍了咪唑环系统，包括咪唑吡啶、咪唑喹啉、6,7,8,9-四氢咪唑喹啉、咪唑萘啶和6,7,8,9-四氢咪唑萘啶化合物，这些化合物在1位和/或2位被取代，以及含有这些化合物的药物组合物，制备这些化合物的方法，以及将这些化合物用作免疫调节剂的方法，用于在动物中诱导细胞因子生物合成和治疗包括病毒性和肿瘤性疾病的方法。
• EPOXY RESIN, METHOD FOR PRODUCING EPOXY RESIN, EPOXY RESIN COMPOSITION, AND CURED ARTICLE
  申请人：Nagase ChemteX Corporation

  公开号：EP2952534A1

  公开（公告）日：2015-12-09

  An object of the present invention is to provide an epoxy resin that does not release compounds suspected of being endocrine-disrupting chemicals, and can be used as a starting material for cured products having excellent surface hardness, excellent chemical resistance, excellent lightfastness, and excellent flexibility. The epoxy resin of the present invention has a number-average molecular weight from 400 to 100,000, and is represented by the following general formula (1) : wherein A represents a heterocyclic structural unit.

  本发明的目的是提供一种环氧树脂，该环氧树脂不会释放出疑似干扰内分泌的化学物质，并可用作固化产品的起始材料，使其具有优异的表面硬度、优异的耐化学性、优异的耐光性和优异的柔韧性。本发明的环氧树脂的数均分子量为 400 至 100 000，其通式如下（1）： ： 其中 A 代表杂环结构单元。

表征谱图